Epstein-Barr virus-associated post-transplant smooth muscle tumours in a kidney transplant patient.

Autor: Cobeñas CJ; Nephrology Department, Hospital de Niños 'Sup. Sor María Ludovica', La Plata, Buenos Aires, Argentina. carlos.cobenas@hotmail.com., Pereyra P; Nephrology Department, Hospital de Niños 'Sup. Sor María Ludovica', La Plata, Buenos Aires, Argentina., Spizzirri AP; Nephrology Department, Hospital de Niños 'Sup. Sor María Ludovica', La Plata, Buenos Aires, Argentina., Gauto Santacruz C; Nephrology Department, Hospital de Niños 'Sup. Sor María Ludovica', La Plata, Buenos Aires, Argentina., Del Carmen Suarez A; Nephrology Department, Hospital de Niños 'Sup. Sor María Ludovica', La Plata, Buenos Aires, Argentina., Altamirano E; Pathology Department, Hospital de Niños 'Sup. Sor María Ludovica', La Plata, Argentina., Pérez P; Pathology Department, Hospital de Niños 'Sup. Sor María Ludovica', La Plata, Argentina., Tello N; Neurosurgery Department, Hospital de Niños 'Sup. Sor María Ludovica', La Plata, Argentina.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2024 Sep 04. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1007/s00467-024-06493-4
Abstrakt: We report on a 14-year-old girl who developed post-transplantation smooth muscle tumours (PTSMT) located in the spleen, lungs, liver, and central nervous system (CNS), 4 years after kidney transplantation. She was asymptomatic, and the disease was detected during the work-up for a urinary tract infection. Diagnosis was performed by the analysis of a tissue specimen, through the biopsy of a lung tumour, which revealed a proliferation of spindle-shaped cells which were positive for actin and vimentin. In situ hybridization studies were positive for Epstein-Barr virus, and her serologic status was negative prior to transplantation. We reduced immunosuppression by stopping mycophenolate and switching tacrolimus for sirolimus. After 18 months of follow-up, she remains asymptomatic, and the CNS tumour reduced its diameter from 24 × 21 mm to 14 × 13 mm. PTSMT should be considered in the differential diagnosis of transplanted patients who develop neoplastic complications associated with immunosuppression.
(© 2024. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
Databáze: MEDLINE
Externí odkaz: