Omeprazole-Associated Atypical Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in a Patient with Positive In Vitro Diagnostic Testing to Multiple Proton Pump Inhibitors.
| Autor: | Grice S; Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, United Kingdom., Hammond S; ApconiX, Alderley Edge SK10 4TG, U.K., Hampson L; Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, United Kingdom., Wagner A; Department of Adult Allergy, Guy's and St Thomas' Hospital, London SE1 9RT, U.K., Naisbitt DJ; Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3GE, United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical research in toxicology [Chem Res Toxicol] 2024 Sep 16; Vol. 37 (9), pp. 1484-1487. Date of Electronic Publication: 2024 Sep 04. |
| DOI: | 10.1021/acs.chemrestox.4c00225 |
| Abstrakt: | Proton pump inhibitors (PPIs) are a commonly used class of drugs with a good safety profile. However, their use is associated with rare cases of severe skin reaction. Herein, we present details of a patient who developed two episodes of omeprazole-induced delayed-onset hypersensitivity (atypical drug reaction with eosinophilia and systemic symptoms [DRESS]). Lymphocytes from the patient were stimulated to proliferate and secrete cytokines and cytolytic molecules when treated with the drug. T-cell cross-reactivity was observed with structurally related PPIs. Hence, other PPIs have the potential to cause further serious immune-related adverse events in patients who present with hypersensitivity to a primary PPI. |
| Databáze: | MEDLINE |
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