Sex Differences in Hypertension and Its Management Throughout Life.

Autor: Yeo WJ; Division of Precision Medicine, Department of Medicine, NYU Langone Health, New York (W.-J.Y., R.A., A.L.S., C.M.F., M.E.G.)., Abraham R; Division of Precision Medicine, Department of Medicine, NYU Langone Health, New York (W.-J.Y., R.A., A.L.S., C.M.F., M.E.G.)., Surapaneni AL; Division of Precision Medicine, Department of Medicine, NYU Langone Health, New York (W.-J.Y., R.A., A.L.S., C.M.F., M.E.G.)., Schlosser P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (P.S., B.O.).; Department of Data Driven Medicine, Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Germany (P.S.).; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Germany (P.S.)., Ballew S; Optimal Aging Institute, NYU Langone Health, New York (S.B., J.C.)., Ozkan B; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (P.S., B.O.)., Flaherty CM; Division of Precision Medicine, Department of Medicine, NYU Langone Health, New York (W.-J.Y., R.A., A.L.S., C.M.F., M.E.G.)., Yu B; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (B.Y.)., Bonventre JV; Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.V.B.)., Parikh C; Division of Nephrology, Department of Medicine, Johns Hopkins University School of MedicineBaltimore, MD (C.P.)., Kimmel PL; Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (P.L.K.)., Vasan RS; School of Public Health, University of Texas Health San Antonio (R.S.V.)., Coresh J; Department of Population Health, NYU Langone Medical Center, New York (J.C., M.E.G.).; Optimal Aging Institute, NYU Langone Health, New York (S.B., J.C.)., Grams ME; Division of Precision Medicine, Department of Medicine, NYU Langone Health, New York (W.-J.Y., R.A., A.L.S., C.M.F., M.E.G.).; Department of Population Health, NYU Langone Medical Center, New York (J.C., M.E.G.).
Jazyk: angličtina
Zdroj: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Sep 04. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1161/HYPERTENSIONAHA.124.22980
Abstrakt: Background: The prevalence of hypertension and uncontrolled hypertension may differ by age and sex.
Methods: We included participants in the Atherosclerosis Risk in Communities study at seven study visits over 33 years (visit 1: 15 636 participants; mean age, 54 years; 55% women), estimating sex differences in prevalence of hypertension (systolic blood pressure ≥130 mm Hg; diastolic blood pressure ≥80 mm Hg; or self-reported antihypertension medication use) and uncontrolled hypertension (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg) using unadjusted and comorbidity-adjusted models.
Results: The prevalence of hypertension increased from 40% (ages, 43-46 years) to 93% (ages, 91-94 years). Within hypertensive individuals, the prevalence of uncontrolled hypertension was higher in men (33%) than women (23%) at ages 43 to 46 years but became higher in women than men starting at ages 61 to 64, with 56% of women and 40% men having uncontrolled hypertension at ages 91 to 94. This sex difference was not explained by differences in coronary heart disease, diabetes, body mass index, estimated glomerular filtration rate, number of antihypertension medications, classes of medications, or adherence to medications. In both sexes, uncontrolled hypertension was associated with a higher risk for chronic kidney disease progression (hazard ratio, 1.5 [1.2-1.9]; P =4.5×10 - 4 ), heart failure (hazard ratio, 1.6 [1.4-2.0]; P =8.1×10 - 7 ), stroke (hazard ratio, 2.1 [1.6-2.8]; P =1.8×10 - 8 ), and mortality (hazard ratio, 1.5 [1.3-1.6]; P =6.2×10 - 19 ).
Conclusions: Sex differences in the prevalence of hypertension and uncontrolled hypertension vary by age, with the latter having implications for health throughout the life course.
Databáze: MEDLINE
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