Ethanolic Extract of Mangifera indica Protects against CCl 4 -Induced Hepatotoxicity via Antioxidant Capabilities in Albino Rats.

Autor: Kabbashi AS; Department of Biomedical Science Faculty of Pharmacy Omar Al-Mukhtar University, Al-Bayda, Libya., Eltawaty SA; Department of Biomedical Science Faculty of Pharmacy Omar Al-Mukhtar University, Al-Bayda, Libya., Ismail AM; Department of Biomedical Science Faculty of Pharmacy Omar Al-Mukhtar University, Al-Bayda, Libya., Elshikh AA; Department of Botany Faculty of Science and Technology Omdurman Islamic University, Omdurman, Sudan., Alrasheid AA; Department of Pharmacognosy Faculty of Pharmacy University of Medical Sciences and Technology, Khartoum, Sudan., Elmahi RA; Department of Histopathology Faculty of Medical Laboratory Sciences International University of Africa, Khartoum, Sudan., Koko WS; Department of Biology College of Science Qassim University, Qassim 51452, Saudi Arabia., Osman EE; Department of Microbiology Faculty of Pure and Applied Science International University of Africa, Khartoum, Sudan.
Jazyk: angličtina
Zdroj: Journal of toxicology [J Toxicol] 2024 Aug 27; Vol. 2024, pp. 5539386. Date of Electronic Publication: 2024 Aug 27 (Print Publication: 2024).
DOI: 10.1155/2024/5539386
Abstrakt: Objective: To investigate the antioxidant and hepatoprotective effects of ethanolic Mangifera indica ( M. indica ) seed extract on carbon tetrachloride (CCl 4 )-induced hepatotoxicity in albino rats.
Methods: Forty-eight albino rats weighing (100-150 g) were used for hepatoprotective and toxicity experiments. Antioxidant activity was determined using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. The toxicity of M. indica seeds on the liver was evaluated by examining wellness parameters, body weight, and liver histological sections. The protective effects of 50 mg/kg and 100 mg/kg of seed extract on CCl 4 -induced hepatotoxicity were investigated by evaluating hematological, renal, and liver function parameters, body weight, and liver histological sections.
Results: The antioxidant activity of the M. indica ethanolic extract was (92 ± 0.03 RSA %) compared with (91 ± 0.01 RSA %) of propyl gallate, and the IC 50 was (8.3 ± 0.01  µ g/ml) and (14.1 ± 0.01  µ g/ml). No changes were observed in the health indicators, body weights, and liver histological sections following oral administration of 50 mg/kg and 100 mg/kg of M. indica seed extracts. Treatment with M. indica seed extract significantly reduced alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), blood sugar, and urea levels compared with those in the CCl 4 -treated group.
Conclusion: The IC 50 of the M. indica ethanolic extract was 8.3  µ g/ml, and the M. indica extract is a potential source of natural antioxidants that protect against CCl 4 -induced hepatotoxicity.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2024 Ahmed Saeed Kabbashi et al.)
Databáze: MEDLINE
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