The CALERIE ™ Genomic Data Resource.

Autor: Ryan CP; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA., Corcoran DL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Banskota N; Intramural Research Program of the National Institute on Aging, NIH - Baltimore, MD-USA., Eckstein IC; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA., Floratos A; Department of Systems Biology, Columbia University Irving Medical Center.; Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center.; Department of Biomedical Informatics, Columbia University Irving Medical Center., Friedman R; Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center.; Department of Biomedical Informatics, Columbia University Irving Medical Center., Kobor MS; BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2A1, Canada.; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada.; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto ON M5G 1M1, Canada.; Edwin S. H. Leong Centre for Healthy Aging, University of British Columbia, Vancouver, BC., Kraus VB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27701, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA., Kraus WE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27701, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA., MacIsaac JL; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada., Orenduff MC; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27701, USA., Pieper CF; Dept of Biostatistics and BioInformatics, Duke University School of Medicine, Durham, NC, USA., White JP; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27701, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA., Ferrucci L; Intramural Research Program of the National Institute on Aging, NIH - Baltimore, MD-USA., Horvath S; Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, USA., Huffman KM; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27701, USA.; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA., Belsky DW; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Jazyk: angličtina
Zdroj: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 22. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1101/2024.05.17.594714
Abstrakt: Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from CALERIE-2 ™ - the first ever randomized, controlled trial of long-term CR in healthy, non-obese humans - broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n=218 participants during the trial. These data constitute the first publicly-accessible genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome SNP genotypes, and three-timepoint-longitudinal DNA methylation, mRNA, and small RNA datasets generated from blood, skeletal muscle, and adipose tissue samples (total sample n=2327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This mult-itissue, multi-omic, longitudinal data resource has great potential to advance translational geroscience.
Competing Interests: Conflict of Interest. DWB and DLC are listed as inventors of the Duke University and University of Otago invention DunedinPACE, which is licensed to TruDiagnostic. DWB is consulting CSO and SAB chair of BellSant and serves on the SAB of the Hooke Clinic.
Databáze: MEDLINE
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