Gestational PFAS exposure and newborn size: The modifying effect of cord blood fatty acids.

Autor:	Gao C; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230031, China.; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230031, China.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230031, China.; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China., Luo L; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230031, China.; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230031, China.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230031, China.; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China., Fan Y; Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China., Guo L; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230031, China.; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230031, China.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230031, China.; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China., Guo L; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230031, China.; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230031, China.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230031, China.; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China., Tao L; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230031, China.; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230031, China.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230031, China.; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China., Tao F; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China.; Department of Maternal & Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230031, China., Xu DX; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230031, China.; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230031, China.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230031, China.; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China., Gibson RA; SAHMRI Women and Kids, South Australian Health and Medical Research Institute, North Adelaide, 5000, South Australia, Australia., Makrides M; SAHMRI Women and Kids, South Australian Health and Medical Research Institute, North Adelaide, 5000, South Australia, Australia., Wang H; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230031, China.; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230031, China.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230031, China.; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China., Huang Y; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230031, China.; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230031, China.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230031, China.; MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, 230031, China.; Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.; Clinical Research Center, Suzhou Hospital of Anhui Medical University, Suzhou, 234099, China.
Jazyk:	angličtina
Zdroj:	Environmental science and ecotechnology [Environ Sci Ecotechnol] 2024 Aug 03; Vol. 22, pp. 100476. Date of Electronic Publication: 2024 Aug 03 (Print Publication: 2024).
DOI:	10.1016/j.ese.2024.100476
Abstrakt:	Per- and polyfluoroalkyl substances (PFASs) can disrupt lipid metabolism, and changes in cord blood fatty acid composition have been observed in small newborns. Emerging evidence suggests that exposure to PFASs during pregnancy is linked to decreased newborn size, although the evidence is not consistent. The modifying effect of fatty acids on the associations of gestational PFAS exposure with newborn size is still unknown. Here we show that the nutritional status of the fetus, as indicated by the level of fatty acids in the cord blood, mitigates the adverse effects of gestational PFAS exposure on the size of the newborn. Our study confirms the adverse developmental effects of PFASs and identifies emerging short-chain PFASs as the primary drivers of reduced newborn size, despite their lower exposure burden compared to legacy PFASs. Additionally, we find the protective role of cord blood fatty acids, suggesting potential strategies for mitigating the detrimental effects of emerging environmental exposures on human health. Our findings provide new evidence of the potential toxicity of emerging PFASs and call for further toxicity evaluations of these pollutants for regulatory purposes. Future studies should consider the complex interaction between exposure and nutrition within the human body, particularly during the first thousand days of life, to promote lifelong health. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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