Reiterated male-to-female violence disrupts hippocampal estrogen receptor β expression, prompting anxiety-like behavior.

Autor:	Agrimi J; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bernardele L; Department of Biomedical Sciences, University of Padova, Padova, Italy., Sbaiti N; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Brondi M; Neuroscience Institute -CNR, Padova, Italy., D'Angelo D; Department of Biomedical Sciences, University of Padova, Padova, Italy., Canato M; Department of Biomedical Sciences, University of Padova, Padova, Italy., Marchionni I; Department of Biomedical Sciences, University of Padova, Padova, Italy., Oeing CU; Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany., Barbara G; Service for Sexual and Domestic Violence, Fondazione IRCSS, Ospedale Maggiore Policlinico, Milan, Italy.; Department of Clinical Science and Community Health, University of Milan, Milan, Italy., Vignoli B; Department of Physics, University of Trento, 38123 Trento, Italy., Canossa M; Department of Cellular, Computational, and Integrative Biology, University of Trento, Trento, Italy., Kaludercic N; Department of Biomedical Sciences, University of Padova, Padova, Italy., Spolverato G; Department of Surgical Oncological and Gastrointestinal Sciences, University of Padova, Padova, Italy., Raffaello A; Department of Biomedical Sciences, University of Padova, Padova, Italy., Lodovichi C; Neuroscience Institute -CNR, Padova, Italy.; Veneto Institute of Molecular Medicine, Padova, Italy.; Padova Neuroscience Center, Padova, Italy., Maschio MD; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Padova Neuroscience Center, Padova, Italy., Paolocci N; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jul 25; Vol. 27 (9), pp. 110585. Date of Electronic Publication: 2024 Jul 25 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.110585
Abstrakt:	Intimate partner violence (IPV) is a significant public health concern whose neurological/behavioral sequelae remain to be mechanistically explained. Using a mouse model recapitulating an IPV scenario, we evaluated the female brain neuroendocrine alterations produced by a reiterated male-to-female violent interaction (RMFVI). RMFVI prompted anxiety-like behavior in female mice whose hippocampus displayed a marked neuronal loss and hampered neurogenesis, namely reduced BrdU-DCX-positive nuclei and diminished dendritic arborization in the dentate gyrus (DG): effects paralleled by a substantial downregulation of the estrogen receptor β (ERβ). After RMFVI, the DG harbored reduced brain-derived neurotrophic factor (BDNF) pools and tyrosine kinase receptor B (TrkB) phosphorylation. Accordingly, ERβ knockout (KO) mice had heightened anxiety and curtailed BDNF levels at baseline while dying prematurely during the RMFVI procedure. Strikingly, injecting an ERβ antagonist or agonist into the wild-type (WT) female hippocampus enhanced or reduced anxiety, respectively. Thus, reiterated male-to-female violence jeopardizes hippocampal homeostasis, perturbing the ERβ/BDNF axis and ultimately instigating anxiety and chronic stress. Competing Interests: The authors declare no conflicts of interests. (© 2024 Published by Elsevier Inc.)
Databáze:	MEDLINE
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