Disentangling the relationship between biological age and frailty in community-dwelling older Mexican adults.

Autor:	Fermín-Martínez CA; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.; MD/PhD (PECEM) Program, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Ramírez-García D; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Antonio-Villa NE; Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., López-Teros MT; Universidad Iberoamericana, Mexico City, Mexico.; Dirección de Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición. Salvador Zubirán, Mexico City, Mexico., Seiglie JA; Diabetes Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Pérez RCC; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico., Peña CG; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico., Gutiérrez-Robledo LM; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico., Bello-Chavolla OY; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.
DOI:	10.1101/2024.08.20.24312308
Abstrakt:	Objective: Older adults have heterogeneous aging rates. Here, we explored the impact of biological age (BA) and accelerated aging on frailty in community-dwelling older adults. Methods: We assessed 735 community-dwelling older adults from the Coyocan Cohort. BA was measured using AnthropoAge, accelerated aging with AnthropoAgeAccel, and frailty using both Fried's phenotype and the frailty index. We explored the association of BA and accelerated aging (AnthropoAgeAccel ≥0) with frailty at baseline and characterized the impact of both on body composition and physical function. We also explored accelerated aging as a risk factor for frailty progression after 3-years of follow-up. Results: Older adults with accelerated aging have higher frailty prevalence and indices, lower handgrip strength and gait speed. AnthropoAgeAccel was associated with higher frailty indices (β=0.0053, 95%CI 0.0027-0.0079), and increased odds of frailty at baseline (OR 1.16, 95%CI 1.09-1.25). We observed a sexual dimorphism in body composition and physical function linked to accelerated aging in non-frail participants; however, this dimorphism was absent in pre-frail/frail participants. Accelerated aging at baseline was associated with higher risk of frailty progression over time (OR 1.74, 95%CI 1.11-2.75). Conclusions: Despite being intertwined, biological accelerated aging is largely independent of frailty in community-dwelling older adults. Competing Interests: CONFLICT OF INTERESTS: The authors declare that they have no conflict of interests.
Databáze:	MEDLINE
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