Blunted cardiac autonomic dynamics to active standing test in postmenopausal women.

Autor:	Scatà C; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Ferreira FC; Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Brazil., Padilha MCSV; Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Brazil., Carandina A; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Asnaghi R; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Bellocchi C; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Tobaldini E; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Montano N; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Soares PPDS; Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Brazil., Rodrigues GD; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Aug 20; Vol. 11, pp. 1402086. Date of Electronic Publication: 2024 Aug 20 (Print Publication: 2024).
DOI:	10.3389/fcvm.2024.1402086
Abstrakt:	Introduction: Although both aging and menopause influence cardiovascular autonomic control, the effect of menopause per se remains unclear. The current study was undertaken to test the hypothesis that post-menopausal women (PMW) have a blunted cardiovascular autonomic adjustment to active standing compared to pre-menopausal women. Thus, we compared the heart rate variability (HRV) indexes from supine (SUP) to orthostatic (ORT) positions among young women (YW), young men (YM), older men (OM), and PMW. Methods: The participants rested for 10 min in SUP and then stood up and remained for 5 min in ORT. ECG was continuously recorded, and R-R time series of about 300 beats were analyzed using linear (spectral analysis) and non-linear (symbolic analysis) methods. The variation from SUP to ORT was calculated ( Δ  = ORT-SUP) for each HRV index. Results: In SUP, no difference was found for any HRV index among groups. However, Δ 0V% and Δ LFn (cardiac sympathetic modulation) were reduced in PWM compared to all groups (OM, YW, and YM), while Δ 2UV% and Δ HFn (cardiac vagal modulation) were reduced in PMW than the younger group (YW and YM). No differences were found among the male groups (OM and YM). Discussion: In light of our results, the cardiac autonomic dynamic response to orthostatic stress is blunted in post-menopausal women compared to younger women and older men, a finding that might be influenced not only by aging. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (© 2024 Scatà, Ferreira, Padilha, Carandina, Asnaghi, Bellocchi, Tobaldini, Montano, Soares and Rodrigues.)
Databáze:	MEDLINE
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