Delayed Ferumoxtran-10-Enhanced Magnetic Resonance Neurography of the Lumbosacral Plexus: Impact on Vascular Suppression and Image Quality.

Autor: Kaniewska M; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ), Zurich, Switzerland.; University of Zurich (UZH), Zurich, Switzerland., Deininger-Czermak E; University of Zurich (UZH), Zurich, Switzerland.; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.; Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland., Ensle F; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ), Zurich, Switzerland.; University of Zurich (UZH), Zurich, Switzerland., Donati OF; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ), Zurich, Switzerland.; University of Zurich (UZH), Zurich, Switzerland.; Radiologie Hirslanden Zurich, Octorad AG, Zürich, Switzerland., Guggenberger R; Institute of Diagnostic and Interventional Radiology, University Hospital Zurich (USZ), Zurich, Switzerland.; University of Zurich (UZH), Zurich, Switzerland.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2024 Sep 04. Date of Electronic Publication: 2024 Sep 04.
DOI: 10.1002/jmri.29604
Abstrakt: Background: Intravenous Ferumoxtran-10 belongs to ultra-small superparamagnetic iron oxide particles and can be used for magnetic resonance neurography (MRN) as an alternative to other imaging methods which use contrast agents.
Purpose: To examine the impact of intravenous Ferumoxtran-10 on vascular suppression and compare image quality to gadolinium (Gd)-enhanced image acquisition in MRN of lumbosacral plexus (LS).
Study Type: Prospective.
Population/subjects: 17 patients with Ferumoxtran-10-enhanced MRN, and 20 patients with Gd-enhanced MRN.
Fieldstrength/sequence: 3T/3D STIR sequence.
Assessment: Image quality, nerve visibility and vascular suppression were evaluated by 3 readers using a 5-point Likert scale.
Statistical Tests: Inter-reader agreement (IRA) was calculated using intraclass coefficients (ICC). Quantitative analysis of image quality was performed by signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) measurements and compared using Student's t-testing.
Results: Image quality, nerve visibility and vascular suppression were significantly higher for Ferumoxtran-10-enhanced MRN compared to Gd-enhanced MRN sequences (p < 0.05). IRA for image quality of nerves was good in Gd-enhanced and Ferumoxtran-10 MRN with ICC values of 0.76 and 0.89, respectively. IRA for nerve visibility was good in Gd- and Ferumoxtran-10 enhanced MR neurography (ICC 0.72 and 0.90). Mean SNR was significantly higher in Ferumoxtran-10-enhanced MRN for all analyzed structures, while mean CNR was for significantly better for S1 ganglion and femoral nerve in Ferumoxtran-10-enhanced MRN (p < 0.05).
Data Conclusion: Ferumoxtran-10-enhanced MRN of the LS plexus showed significantly higher image quality and nerve visibility with better vascular suppression as compared to Gd-enhanced MRN.
Evidence Level: 2 TECHNICAL EFFICACY: Stage 3.
(© 2024 The Author(s). Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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