MRI Indices of Glymphatic Function Correlate With Disease Duration in Idiopathic Intracranial Hypertension.

Autor:	Bouffard MA; Departments of Neurology (MB, BA), Radiology (MAA, NJ, AB, DA, DSC, Y-MC), and Surgery (NT), Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Ophthalmology (MB, BA), Massachusetts Eye and Ear, Boston, Massachusetts; and Department of Radiology (JF), Massachusetts General Hospital, Boston, Massachusetts., Avanaki MA, Ford JN, Jaafar N, Brook A, Abbasi B, Torun N, Alsop D, Comeau DS, Chang YM
Jazyk:	angličtina
Zdroj:	Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society [J Neuroophthalmol] 2024 Sep 04. Date of Electronic Publication: 2024 Sep 04.
DOI:	10.1097/WNO.0000000000002259
Abstrakt:	Background: The glymphatic system represents an extravascular network of astrocytic channels responsible for interstitial fluid and solute transit through the brain parenchyma. Its dysfunction has been considered as a possible cause of idiopathic intracranial hypertension (IIH). Methods: We enrolled participants with active IIH, treated or cured IIH, and controls. The active IIH group was divided into untreated participants with recently developed (<6 mo) and chronic (6+ mo) disease. Glymphatic function was assessed using diffusion tensor imaging along the paravascular space (DTI-ALPS) to generate an ALPS-index, hypothesized to measure glymphatic function. Participants were imaged before lumbar puncture (LP) if IIH was suspected and following LP when possible. Results: ALPS indices were higher in participants with chronically present, active IIH than in those either with recently developed IIH or control participants. ALPS-indices correlated with papilledema but did not correlate significantly with age, BMI, or intracranial pressure (ICP). Conclusions: Our findings suggest that DTI-ALPS-indices of glymphatic function may be influenced by the chronicity of intracranial hypertension but do not support the hypothesis that glymphatic dysfunction causes IIH. Though these findings are preliminary, glymphatic imaging may be a useful radiographic biomarker in IIH. Competing Interests: The authors report no conflicts of interest. (Copyright © 2024 by North American Neuro-Ophthalmology Society.)
Databáze:	MEDLINE
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