Correlation analysis of cofilin-1 with renal prognosis in primary IgA nephropathy.

Autor: Zhao RB; Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning City, 530021, Guangxi Province, China., Xu YS; Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning City, 530021, Guangxi Province, China., Li XH; Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning City, 530021, Guangxi Province, China., Wei MJ; Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning City, 530021, Guangxi Province, China., Deng Y; Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning City, 530021, Guangxi Province, China., Peng X; Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning City, 530021, Guangxi Province, China., Pan L; Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning City, 530021, Guangxi Province, China. panling@gxmu.edu.cn.
Jazyk: angličtina
Zdroj: BMC nephrology [BMC Nephrol] 2024 Sep 03; Vol. 25 (1), pp. 289. Date of Electronic Publication: 2024 Sep 03.
DOI: 10.1186/s12882-024-03723-7
Abstrakt: Purpose: The purpose of this study was to investigate the correlation between podocyte related biomarker cofilin-1 and renal function, and explore the value of cofilin-1 in predicting the risk of renal adverse prognosis in IgA nephropathy (IgAN).
Methods: Patients with primary IgAN diagnosed by initial renal biopsy performed in our hospital from January 2019 to February 2022 were included. This study was a prospective cohort study. All IgAN patients were detected the expression of cofilin-1 and other related biomarkers (RhoA, NGAL) in urine by enzyme-linked immunosorbent assay (ELISA) and follow-up at least 6 months. We also collected baseline clinicopathologial data of IgAN. The decreased renal function group was defined as baseline eGFR < 60 ml/min/1.73m 2 . Logistic and Cox regression model were used to analyze the correlation among cofilin-1 and renal prognosis.
Results: 133 IgAN patients were included, with a male-to-female ratio of 1.25:1 and an age of 37.67 ± 13.78 years, as well as an average of eGFR was 71.63 (40.42,109.33) ml/min/1.73m 2 . 56 patients (42.1%) had decreased renal function at baseline, with the average of eGFR was 34.07 (16.72, 49.21) ml/min/1.73 m 2 . 12 of which developed to renal adverse prognosis. The average of follow-up time was 22.035 ± 8.992 months. The multivariate regression analysis showed that increased urinary cofilin-1 was an independent risk factor associated with baseline renal function decline and renal adverse prognosis in IgAN patients (P < 0.05). ROC curves showed great efficacy of urinary cofilin-1 levels in diagnosing baseline renal function decline and predicting renal adverse prognosis (the area under the ROC curve was 0.708 and 0.803).
Conclusion: Cofilin-1 as a novel biomarker of podocyte lesion is closely related to renal function decline in IgAN. Cofilin-1 has certain clinical value in predicting the risk of renal adverse prognosis. Podocyte fusion affects the renal prognosis of IgAN.
(© 2024. The Author(s).)
Databáze: MEDLINE
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