Age differences in BOLD modulation to task difficulty as a function of amyloid burden.

Autor:	Hennessee JP; Center for Vital Longevity; Department of Psychology, School of Behavioral and Brain Sciences, University of Texas at Dallas, 1600 Viceroy Dr., Suite 800, Dallas, TX 75235, United States., Lung TC; Center for Vital Longevity; Department of Psychology, School of Behavioral and Brain Sciences, University of Texas at Dallas, 1600 Viceroy Dr., Suite 800, Dallas, TX 75235, United States., Park DC; Center for Vital Longevity; Department of Psychology, School of Behavioral and Brain Sciences, University of Texas at Dallas, 1600 Viceroy Dr., Suite 800, Dallas, TX 75235, United States.; Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, United States., Kennedy KM; Center for Vital Longevity; Department of Psychology, School of Behavioral and Brain Sciences, University of Texas at Dallas, 1600 Viceroy Dr., Suite 800, Dallas, TX 75235, United States.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Sep 03; Vol. 34 (9).
DOI:	10.1093/cercor/bhae357
Abstrakt:	Effective cognitive performance often requires the allocation of additional neural resources (i.e. blood-oxygen-level-dependent [BOLD] activation) as task demands increase, and this demand-related modulation is affected by amyloid-beta deposition and normal aging. The present study investigated these complex relationships between amyloid, modulation, and cognitive function (i.e. fluid ability). Participants from the Dallas Lifespan Brain Study (DLBS, n = 252, ages 50-89) completed a semantic judgment task during functional magnetic resonance imaging (fMRI) where the judgments differed in classification difficulty. Amyloid burden was assessed via positron emission tomography (PET) using 18F-florbetapir. A quadratic relationship between amyloid standardized value uptake ratios (SUVRs) and BOLD modulation was observed such that modulation was weaker in those with moderately elevated SUVRs (e.g. just reaching amyloid-positivity), whereas those with very high SUVRs (e.g. SUVR > 1.5) showed strong modulation. Greater modulation was related to better fluid ability, and this relationship was strongest in younger participants and those with lower amyloid burden. These results support the theory that effective demand-related modulation contributes to healthy cognitive aging, especially in the transition from middle age to older adulthood, whereas high modulation may be dysfunctional in those with substantial amyloid deposition. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
Databáze:	MEDLINE
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