Application of polysaccharide-based crosslinking agents based on schiff base linkages for biomedical scaffolds.

Autor: Zhang L; College of traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China., Yang J; College of traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China., Ding C; College of traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China., Sun S; College of traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China., Zhang S; College of traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China., Ding Q; College of traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China., Zhao T; College of traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China. Electronic address: lyguiwandingding@163.com., Liu W; School of Food and Pharmaceutical Engineering, Wuzhou University, Wuzhou 543002, China. Electronic address: jwlw6803@126.com.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2024 Dec 01; Vol. 345, pp. 122585. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1016/j.carbpol.2024.122585
Abstrakt: Chemical crosslinking is a method widely used to enhance the mechanical strength of biopolymer-based scaffolds. Polysaccharides are natural and biodegradable carbohydrate polymers that can act as crosslinking agents to promote the formation of scaffolds. Compared to synthetic crosslinking agents, Polysaccharide-based crosslinking agents have better biocompatibility for cell adhesion and growth. Traditional Chinese medicine has special therapeutic effects on various diseases and is rich in various bioactive ingredients. Among them, polysaccharides have immune regulatory, antioxidant, and anti-inflammation effects, which allow them to not only act as crosslinking agents but endow the scaffold with greater bioactivity. This article focuses on the latest developments of polysaccharide-based crosslinking agents for biomedical scaffolds, including hyaluronic acid, chondroitin sulfate, dextran, alginate, cellulose, gum polysaccharides, and traditional Chinese medicine polysaccharides. Also, we provide a summary and prospects on the research of polysaccharide-based crosslinking agents.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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