Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit.

Autor: Carcelen AC; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Kong AC; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Takahashi S; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Hegde S; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Jaenisch T; Colorado School of Public Health, Aurora, Colorado., Chu M; Colorado School of Public Health, Aurora, Colorado., Rochford R; Colorado School of Public Health, Aurora, Colorado., Kostandova N; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Gurley ES; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Wesolowski A; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Azman AS; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Geneva University Hospitals, Geneva, Switzerland., van der Klis FRM; Center for Infectious Disease Control National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., den Hartog G; Center for Infectious Disease Control National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.; Laboratory of Medical Immunology, Radboud UMC, Nijmegen, The Netherlands., Drakeley C; London School of Tropical Medicine and Health, London, United Kingdom., Heaney CD; Environmental Health and Engineering Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Winter AK; University of Georgia, Athens, Georgia., Salje H; Department of Genetics, University of Cambridge, Cambridge, United Kingdom., Rodriguez-Barraquer I; Department of Medicine, University of California, San Francisco, California., Leung DT; Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, Utah., Njenga SM; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya., Kagucia EW; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Jambo KC; Malawi-Liverpool-Wellcome Programme (MLW), Blantyre, Malawi.; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Wolter N; Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Charles RC; Massachusetts General Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Saboyá-Díaz MI; Department of Communicable Diseases Prevention, Control, and Elimination, Pan American Health Organization, Washington, District of Columbia., Martin DL; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia., Moss WJ; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Jazyk: angličtina
Zdroj: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2024 Sep 03; Vol. 111 (5), pp. 1145-1152. Date of Electronic Publication: 2024 Sep 03 (Print Publication: 2024).
DOI: 10.4269/ajtmh.24-0296
Abstrakt: Multiplex-based serological surveillance is a valuable but underutilized tool to understand gaps in population-level exposure, susceptibility, and immunity to infectious diseases. Assays for which blood samples can be tested for antibodies against several pathogens simultaneously, such as multiplex bead immunoassays, can more efficiently integrate public health surveillance in low- and middle-income countries. On March 7-8, 2023 a group of experts representing research institutions, multilateral organizations, private industry, and country partners met to discuss experiences, identify challenges and solutions, and create a community of practice for integrated, multi-pathogen serosurveillance using multiplex bead assay technologies. Participants were divided into six working groups: 1) supply chain; 2) laboratory assays; 3) seroepidemiology; 4) data analytics; 5) sustainable implementation; and 6) use case scenarios. These working groups discussed experiences, challenges, solutions, and research needs to facilitate integrated, multi-pathogen serosurveillance for public health. Several solutions were proposed to address challenges that cut across working groups.
Databáze: MEDLINE