Unveiling the immune-modulating power of THz-FEL irradiation.

Autor: Zhang Q; Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, China., Wang W; China Academy of Engineering Physics, Institute of Applied Electronics, Mianyang 621900, Sichuan, China; National Key Laboratory of Science and Technology on Advanced Laser and High Power Microwave, Mianyang 621900, Sichuan, China., Shang S; Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, China., Li X; Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, China., Zhao T; Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, China., Zhang P; China Academy of Engineering Physics, Institute of Applied Electronics, Mianyang 621900, Sichuan, China; National Key Laboratory of Science and Technology on Advanced Laser and High Power Microwave, Mianyang 621900, Sichuan, China., Wu D; China Academy of Engineering Physics, Institute of Applied Electronics, Mianyang 621900, Sichuan, China; National Key Laboratory of Science and Technology on Advanced Laser and High Power Microwave, Mianyang 621900, Sichuan, China., Zhou K; China Academy of Engineering Physics, Institute of Applied Electronics, Mianyang 621900, Sichuan, China; National Key Laboratory of Science and Technology on Advanced Laser and High Power Microwave, Mianyang 621900, Sichuan, China. Electronic address: liming@caep.cn., Lu X; Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, China. Electronic address: luxy05@xjtu.edu.cn.
Jazyk: angličtina
Zdroj: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2024 Oct; Vol. 259, pp. 113017. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1016/j.jphotobiol.2024.113017
Abstrakt: As terahertz (THz) technology advances, the interaction between THz radiation and the living body, particularly its effects on the immune system, has attracted extensive attention but remains poorly understood. This study firstly elucidated that exposure to 3 THz-FEL radiation markedly suppressed contact hypersensitivity reactions in mice induced by DNFB, as evidenced by a reduction in ear thickness and a discernible recovery in the Th1/Th2 cell balance. 3 THz irradiation led to cellular stress in the irradiated skin locale, increasing the levels of IL-4 and IL-10 and modulating the activity and migration of dendritic cells and mast cells. Furthermore, THz irradiation precipitated a rapid alteration in the skin lipidome, altering several categories of bioactive lipids. These findings offer new insights into the immunomodulatory effects of THz radiation on living organisms and the potential underlying mechanisms, with implications for the development of therapeutic approaches in managing skin allergic diseases.
Competing Interests: Declaration of competing interest The authors declare no competing interests.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: