Association between type of menopause and mild cognitive impairment: The REDLINC XII study.

Autor: Espinoza MT; Unidad de Ginecología Obstétrica, Clínica Los Ángeles, Cochabamba, Bolivia., Blümel JE; Medicina Interna Sur, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address: jeblumelm@gmail.com., Chedraui P; Escuela de Posgrado en Salud, Universidad Espíritu Santo, Samborondón, Ecuador., Vallejo MS; Obstetricia y Ginecología, Hospital Clínico, Universidad de Chile, Santiago, Chile., Ñañez M; II Cátedra de Ginecología, Universidad Nacional de Córdoba, Córdoba, Argentina., Ojeda E; Departamento Académico de Medicina Humana, Universidad Andina del Cusco, Cusco, Peru., Rey C; Asociación Argentina para el Estudio del Climaterio, Buenos Aires, Argentina., Rodríguez D; Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Buenos Aires, Argentina., Rodrigues MA; Department of Gynecology and Obstetrics, Federal University of Minas Gerais, Belo Horizonte, Brazil., Salinas C; Servicio de Obstetricia y Ginecología, Hospital Ángeles, Puebla, Mexico., Tserotas K; Clínica Tserotas, Ciudad de Panamá, Panamá., Calle A; Centro Integral de Salud Obstétrica y Femenina. Ginecología, Universidad Indoamérica, Academia Ecuatoriana de Medicina, Quito, Ecuador., Dextre M; Ginecología Obstetricia, Clínica Internacional - Clínica Javier Prado, Lima, Peru., Elizalde A; Departamento de la Mujer, Niñez y Adolescencia, Facultad de Medicina de la Universidad Nacional del Nordeste, Corrientes, Argentina., Escalante C; Departamento de Ginecología, Facultad de Medicina, Universidad de Costa Rica, Costa Rica., Gómez-Tabares G; Departamento de Ginecología, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali, Colombia. Electronic address: gustavo.gomez.tabares@correounivalle.edu.co., Monterrosa-Castro Á; Grupo de Investigación Salud de la Mujer, Universidad de Cartagena, Cartagena, Colombia.
Jazyk: angličtina
Zdroj: Maturitas [Maturitas] 2024 Nov; Vol. 189, pp. 108110. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1016/j.maturitas.2024.108110
Abstrakt: Objective: To evaluate the association between type of menopause (spontaneous or surgical) and mild cognitive impairment (MCI).
Study Design: This study was a cross-sectional, observational, and sub-analytical investigation conducted within gynecological consultations across nine Latin American countries.
Method: We assessed sociodemographic, clinical, and anthropometric data, family history of dementia, and the presence of MCI using the Montreal Cognitive Assessment (MoCA) tool.
Results: The study involved 1185 postmenopausal women with a mean age of 55.3 years and a body mass index of 26.4 kg/m 2 . They had an average of 13.3 years of education, and 37 % were homemakers. Three hundred ninety-nine experienced menopause before 40, including 136 with surgical menopause (bilateral oophorectomy). Out of the 786 women who experienced menopause at 40 or more years, 110 did so due to bilateral oophorectomy. There were no differences in MoCA scores among women who experienced menopause before or after the age of 40. However, lower MoCA scores were observed in women with surgical menopause than in those with spontaneous menopause (23.8 ± 4.9 vs. 25.0 ± 4.3 points, respectively, p < 0.001). Our logistic regression model with clustering of patients within countries found a significant association between MCI and surgical menopause (OR 1.47, 95 % CI: 1.01-2.16), use (ever) of menopausal hormone therapy (OR 0.33, 95 % CI: 0.21-0.50), and having >12 years of education (OR 0.21, 95 % CI: 0.14-0.30).
Conclusion: When comparing women who experience spontaneous menopause over the age of 40 with those who undergo it before this age, there was no observed increased risk of developing MCI, while those with surgical menopause, independent of age, are more prone to cognitive decline. Women who have ever used menopausal hormone therapy have a lower MCI risk. Further research is warranted to delve deeper into this topic.
Competing Interests: Declaration of competing interest The authors declare that they have no competing interest.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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