An overview of Buruli ulcer in Australia.

Autor:	Wong CCW; MD, BParaSci, GradCertClinEd, Infectious Disease Registrar, Victorian Infectious Disease Service, The Royal Melbourne Hospital, Melbourne, Vic., Muhi S; BSc, BMedSc, MBBS, MPHTM, MClinEd, FACTM, FFTM, FRACP, Infectious Diseases Physician, Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Vic; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Vic., O'Brien D; MBBS, FRACP, DMedSc, DipAnat, Deputy Director, Department of Infectious Diseases, Barwon Health, Geelong, Vic; Department of Medicine and Infectious Diseases, Royal Melbourne Hospital, Melbourne, Vic.
Jazyk:	angličtina
Zdroj:	Australian journal of general practice [Aust J Gen Pract] 2024 Sep; Vol. 53 (9), pp. 671-674.
DOI:	10.31128/AJGP-08-23-6914
Abstrakt:	Background: Buruli ulcer (BU) is caused by Mycobacterium ulcerans, an environmental pathogen that causes severe skin and soft-tissue necrosis. In Australia, cases of BU are acquired in endemic regions, which include Victoria and Far North Queensland, but those who have visited these regions can present to health practitioners anywhere. Objective: This article provides Australian general practitioners with an overview of BU, including its epidemiology, transmission, clinical features, diagnosis and management. Discussion: BU can manifest as an ulcer or as a non-ulcerated skin lesion, such as a plaque, nodule or oedema. Diagnosis can be achieved with a dedicated Mycobacterium ulcerans polymerase chain reaction (PCR) test performed on a wound swab. Swabs on non-ulcerated disease have a high false negative rate, and a PCR test should be performed on a tissue biopsy to confirm disease. Most cases are managed with prolonged antibiotic therapy - commonly a combination of oral rifampicin and clarithromycin or fluroquinolone (moxifloxacin or ciprofloxacin) - and wound dressings.
Databáze:	MEDLINE
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