Assessment of photodynamic therapy with annatto and led for the treatment of halitosis in mouth-breathing children: Randomized controlled clinical trial.

Autor: Bruno LH; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.; Universidad Católica del Uruguay (UCU), Montevideo, Uruguay., Mandetta ARH; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil., Sobral APT; Postgraduation Program in Health and Environment, Universidade Metropolitana de Santos, Santos, Brazil.; School of Dentistry, Universidade Metropolitana de Santos, Santos, Brazil., Leal Gonçalves ML; Postgraduation Program in Health and Environment, Universidade Metropolitana de Santos, Santos, Brazil.; School of Dentistry, Universidade Metropolitana de Santos, Santos, Brazil., Santos EM; Postgraduation Program in Health and Environment, Universidade Metropolitana de Santos, Santos, Brazil.; School of Dentistry, Universidade Metropolitana de Santos, Santos, Brazil., Fossati AL; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.; Universidad Católica del Uruguay (UCU), Montevideo, Uruguay., Gallo JMAS; Postgraduation Program in Veterinary Medicine in the Coastal Environment, Universidade Metropolitana de Santos, Santos, Brazil., Motta PB; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil., Deana AM; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil., Horliana ACRT; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil., Motta LJ; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil., Ferrari RAM; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil., Santos Fernandes KP; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil., Kalil Bussadori S; Postgraduation Program in Biophotonic Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.; School of Dentistry, Universidade Metropolitana de Santos, Santos, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Sep 03; Vol. 19 (9), pp. e0307957. Date of Electronic Publication: 2024 Sep 03 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0307957
Abstrakt: Objective: To assess the effectiveness of antimicrobial photodynamic therapy (aPDT) employing an annatto-based (20%) dye combined with blue LED for the treatment of halitosis in mouth-breathing children.
Materials and Methods: Fifty-two children six to twelve years of age with diagnoses of mouth breathing and halitosis (score of ≥ 3 on portable breath meter) Breath Alert™ (Tanita Corporation®-Japan), were randomly allocated to two groups (n = 26). Group 1: brushing, dental floss and aPDT applied to middle third of the dorsum of the tongue. Group 2: brushing, dental floss and tongue scraper. Breath meter results before, immediately after treatment as well as seven and 30 days after treatment were compared. The hypothesis of normality in the data was discarded by the Shapiro-Wilk test (p < 0.05) and for statistical analysis the Wilcoxon and Mann-Whitney tests were used.
Results: A significant difference was found between the pre-treatment reading and all other readings (p < 0.05) in both groups, suggesting the effectiveness of the proposed treatments. No significant difference was found between the post-treatment reading and two follow-up readings, suggesting the maintenance of the effect of treatment over time (p > 0.05). However, significant differences were found between groups for all post-treatment assessments (p < 0.0001 for all comparisons), indicating greater effectiveness with aPDT. No association was found between the initial reading and the presence of coated tongue.
Conclusion: Antimicrobial photodynamic therapy using annatto and blue LED proved to be a viable therapeutic option for the treatment of halitosis in mouth-breathing children.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Bruno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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