Impact of Electric Field Magnitude in the Left Dorsolateral Prefrontal Cortex on Changes in Intrinsic Functional Connectivity Using Transcranial Direct Current Stimulation: A Randomized Crossover Study.

Autor: Kim E; Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Republic of Korea.; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Yun SJ; Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Human Systems Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Oh BM; Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Institute on Aging, Seoul National University, Seoul, Korea., Seo HG; Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jazyk: angličtina
Zdroj: Journal of neuroscience research [J Neurosci Res] 2024 Sep; Vol. 102 (9), pp. e25378.
DOI: 10.1002/jnr.25378
Abstrakt: This study investigated whether the electric field magnitude (E-field) delivered to the left dorsolateral prefrontal cortex (L-DLPFC) changes resting-state brain activity and the L-DLPFC resting-state functional connectivity (rsFC), given the variability in tDCS response and lack of understanding of how rsFC changes. Twenty-one healthy participants received either 2 mA anodal or sham tDCS targeting the L-DLPFC for 10 min. Brain imaging was conducted before and after stimulation. The fractional amplitude of low-frequency fluctuation (fALFF), reflecting resting brain activity, and the L-DLPFC rsFC were analyzed to investigate the main effect of tDCS, main effect of time, and interaction effects. The E-field was estimated by modeling tDCS-induced individual electric fields and correlated with fALFF and L-DLPFC rsFC. Anodal tDCS increased fALFF in the left rostral middle frontal area and decreased fALFF in the midline frontal area (FWE p < 0.050), whereas sham induced no changes. Overall rsFC decreased after sham (positive and negative connectivity, p = 0.001 and 0.020, respectively), with modest and nonsignificant changes after anodal tDCS (p = 0.063 and 0.069, respectively). No significant differences in local rsFC were observed among the conditions. Correlations were observed between the E-field and rsFC changes in the L-DLPFC (r = 0.385, p = 0.115), left inferior parietal area (r = 0.495, p = 0.037), and right lateral visual area (r = 0.683, p = 0.002). Single-session tDCS induced resting brain activity changes and may help maintain overall rsFC. The E-field in the L-DLPFC is associated with rsFC changes in both proximal and distally connected brain regions to the L-DLPFC.
(© 2024 The Author(s). Journal of Neuroscience Research published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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