Common progenitor origin for Rosai-Dorfman disease and clear cell sarcoma.

Autor: Sato A; Department of Hematology and Oncology, The Institute of Medical Science Research Hospital, The University of Tokyo, Tokyo, Japan., Yusa N; Department of Laboratory Medicine, The Institute of Medical Science Research Hospital, The University of Tokyo, Tokyo, Japan., Takamori H; Division of Hematopoietic Disease Control, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Shimizu E; Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Yokoyama K; Department of Hematology and Oncology, The Institute of Medical Science Research Hospital, The University of Tokyo, Tokyo, Japan., Ichikawa S; Department of Hematology, Tohoku University Hospital, Sendai, Japan.; Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan., Yokoyama H; Department of Hematology, Tohoku University Hospital, Sendai, Japan.; Division of Hematology and Cell Therapy, Yamagata University Hospital, Yamagata, Japan., Kasahara Y; Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan., Enda K; Department of Pathology, Tohoku University Hospital, Sendai, Japan., Fujishima F; Department of Pathology, Tohoku University Hospital, Sendai, Japan.; Division of Diagnostic Pathology, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Ichinohasama R; Division of Hematopathology, Tohoku University Hospital, Sendai, Japan., Ota Y; Department of Diagnostic Pathology, The Institute of Medical Science Research Hospital, The University of Tokyo, Tokyo, Japan., Imoto S; Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Nannya Y; Department of Hematology and Oncology, The Institute of Medical Science Research Hospital, The University of Tokyo, Tokyo, Japan.; Division of Hematopoietic Disease Control, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Jazyk: angličtina
Zdroj: The Journal of pathology [J Pathol] 2024 Nov; Vol. 264 (3), pp. 243-249. Date of Electronic Publication: 2024 Sep 03.
DOI: 10.1002/path.6345
Abstrakt: Histiocytic neoplasms (HNs) in adults have been reported to be associated with a high prevalence of coexisting haematological and solid malignancies. While a proportion of coexisting HNs and haematological malignancies share identical genetic alterations, the genetic association between HNs and solid malignancies has scarcely been reported. We report a case of Rosai-Dorfman disease (RDD) complicated by coexisting clear cell sarcoma (CCS). RDD is a rare HN. CCS is an ultrarare soft tissue sarcoma with a poor prognosis. Mutation analysis with whole-exome sequencing revealed six shared somatic alterations including NRAS p.G12S and TP53 c.559+1G>A in both the RDD and CCS tissue. This is the first evidence of a clonal relationship between RDD and solid malignancies using mutational analysis. We hypothesise that neural crest cells, which originate in CCS, are likely the common cells of origin for RDD and CCS. This case helps to unravel the underlying clinicopathological mechanisms of increased association of solid malignancies in HNs. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
(© 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.)
Databáze: MEDLINE
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