Are important predictors of adverse outcome in children with symptomatic congenital cytomegalovirus infection overlooked in clinical settings?

Autor:	Đaković I; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia., Kostović I; Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia., Vulin K; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia., Prvčić I; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia., Tešović G; University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', University of Zagreb School of Medicine, Zagreb, Croatia., Krakar G; Polyclinic Dr. Sabol, Zagreb, Croatia., Gojmerac T; Children's Hospital Srebrnjak, Zagreb, Croatia., Sekelj Fureš J; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.; Faculty of Medicine, University of Osijek, Osijek, Croatia., Mejaški Bošnjak V; Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
Jazyk:	angličtina
Zdroj:	The Journal of international medical research [J Int Med Res] 2024 Sep; Vol. 52 (9), pp. 3000605241274226.
DOI:	10.1177/03000605241274226
Abstrakt:	Objective: Congenital cytomegalovirus infection (cCMV) is a common, frequently unrecognized cause of childhood disability. The aim of the present study was to determine the symptoms that raise the suspicion of cCMV, define the neurodevelopmental outcomes, and assess their correlations. Methods: This longitudinal observational study comprised 78 children with symptomatic cCMV who underwent neuropediatric follow-up for 4 to 17.9 years. Results: Symptoms of central nervous system involvement, hearing/visual impairments, and hepatic involvement were mostly recognized. The average age of disease suspicion was 3.3 months. In terms of outcomes, 10.53% of the children developed complex minor neurological dysfunction and 23.68% developed cerebral palsy. Visual and hearing impairments occurred in 38.16% and 14.47% of patients, respectively. Intellectual disability was present in 30.26% of patients, and epilepsy in 21.05%. Microcephaly and hearing impairment was significantly associated with overall neurodevelopmental outcome. Microcephaly was also associated with poor motor outcomes, hearing impairment, and severe visual impairment. Furthermore, microcephaly and intrauterine growth restriction were significantly associated with poor cognitive outcomes. Conclusion: Symptoms that raised the suspicion of cCMV-especially microcephaly, hearing impairment, and intrauterine growth restriction-were important parameters that were associated with outcomes; however, their recognition was often insufficient and/or late. Competing Interests: Declaration of conflicting interestThe authors declare that there is no conflict of interest.
Databáze:	MEDLINE
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