Real-world outcomes of micropulse transscleral laser therapy in glaucoma patients: Efficacy of initial and repeated treatment, transient intraocular pressure spikes.
| Autor: | Dervos T; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Fortuna LL; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Gugleta K; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Scholl HPN; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.; Institute of Molecular and Clinical Ophthalmology Basel (IOB), Switzerland., Gatzioufas Z; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Hasler PW; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Arabin V; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Enz TJ; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2024 Aug 10; Vol. 10 (16), pp. e36019. Date of Electronic Publication: 2024 Aug 10 (Print Publication: 2024). |
| DOI: | 10.1016/j.heliyon.2024.e36019 |
| Abstrakt: | Purpose: To investigate the clinical outcomes of micropulse transscleral laser therapy (MP-TLT) in a cohort of glaucoma patients, including safety profile, post-operative transient intraocular pressure (IOP) spikes, long-term efficacy and prognostic factors in terms of IOP-lowering. Methods: This was a retrospective observational cohort study. Medical records of all patients who consecutively underwent MP-TLT between May 2019 and February 2023 at a tertiary referral centre were scrutinised and relevant data were retrospectively analysed. Results: A total of 131 patients (138 eyes) with a mean age of 73.2 ± 14.2 years were included. Mean pre-interventional IOP was 24.1 ± 9.1 mmHg. Within 6-12 h following the intervention on the same day, an IOP spike was regularly observed, reaching on average 31.7 ± 10.3 mmHg ( p < 0.001 to baseline). Two years after the intervention, mean IOP was 16.1 ± 5.6 mmHg ( p < 0.005 to baseline). In 18 eyes, the treatment was repeated, and the IOP lowering effect was more durable after the second intervention compared to the first one (Cox-Mantel test, p =<0.005). Apart from the transient post-interventional IOP spikes, no severe complications were observed. Conclusions: MP-TLT is associated with significant IOP spikes in the first post-operative hours. Thus, close post-interventional IOP monitoring or even preventive (additional) IOP-lowering treatment may be considered. In the long term, the procedure yields favourable outcomes in terms of safety and IOP reduction. Repeated MP-TLT treatment, if necessary, seems to achieve more sustained IOP reduction than the initial treatment. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
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