Sheep and goats as reservoirs of colistin-resistant E. coli: first detection of ETEC ST10 and E. coli ST6396 mcr-1 positive strains in North Africa.

Autor:	Boukli-Hacene F; Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology - Houari Boumediene, Bab Ezzouar, Algiers 16111, Algeria., Djouadi LN; Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology - Houari Boumediene, Bab Ezzouar, Algiers 16111, Algeria., Raddaoui A; Laboratory ward, National Bone Marrow Transplant Center, 1006 Tunis, Tunisia.; Faculty of Medicine of Tunis LR18ES39, University of Tunis El Manar, 1006 Tunis, Tunisia., Hachem Y; Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology - Houari Boumediene, Bab Ezzouar, Algiers 16111, Algeria., Boumerdassi H; Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology - Houari Boumediene, Bab Ezzouar, Algiers 16111, Algeria., Achour W; Laboratory ward, National Bone Marrow Transplant Center, 1006 Tunis, Tunisia.; Faculty of Medicine of Tunis LR18ES39, University of Tunis El Manar, 1006 Tunis, Tunisia., Nateche F; Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Science and Technology - Houari Boumediene, Bab Ezzouar, Algiers 16111, Algeria.
Jazyk:	angličtina
Zdroj:	Journal of applied microbiology [J Appl Microbiol] 2024 Sep 02; Vol. 135 (9).
DOI:	10.1093/jambio/lxae227
Abstrakt:	Aim: This study aimed to screen and characterize colistin-resistant strains isolated from different livestock species in Algeria, including sheep, goats, and dromedaries. Methods and Results: A total of 197 rectal and nasal swabs were screened for colistin-resistant Gram-negative bacilli. Twenty one isolates were selected, identified, and their antibiotic resistance was phenotypically and genotypically characterized. The majority (15/21) were affiliated to Escherichia coli, from which 4 strains isolated from sheep (n = 2) and goats (n = 2) and belonging to phylogroup A and ST10 and ST6396 lineages, respectively, carried the mcr-1 gene. The remaining isolates were identified as belonging to the following genera: Raoultella, Enterobacter, Klebsiella, and Pseudomonas. Conclusion: This study highlights the presence of virulent and multiresistant Gram-negative bacilli in farm animals, increasing the risk of transmitting potentially fatal infections to humans. (© The Author(s) 2024. Published by Oxford University Press on behalf of Applied Microbiology International.)
Databáze:	MEDLINE
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