Nailfold capillaroscopy for diagnosis of onychodystrophies: A prospective cross-sectional study.

Autor: Hwang JK; Department of Dermatology, Weill Cornell Medicine, New York, New York., Miller RC; Department of Dermatology, Weill Cornell Medicine, New York, New York., Lipner SR; Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address: shl9032@med.cornell.edu.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2025 Jan; Vol. 92 (1), pp. 51-57. Date of Electronic Publication: 2024 Sep 01.
DOI: 10.1016/j.jaad.2024.08.051
Abstrakt: Background: Nail diseases are often associated with significant physical and psychosocial burden, but diagnosis is challenging due to nonspecific clinical and histological findings. Nailfold capillaroscopy has been studied for the diagnosis of systemic diseases, but studies on nail diseases are lacking.
Objective: The objectives of our study were to characterize and compare capillary changes in a set of nail conditions versus controls, between nail groups, and based on demographic/clinical criteria.
Methods: This was a prospective cross-sectional study of patients with nail psoriasis, onychomycosis, idiopathic onycholysis, brittle nail syndrome, nail lichen planus, retronychia, other nail conditions, and no nail findings (controls) undergoing capillaroscopy imaging/analysis.
Results: Nail psoriasis versus control patients demonstrated decreased capillary length/density and increased abnormal capillaries, with higher frequency in older, male patients. Onychomycosis was associated with increased meandering capillaries compared with controls, nail psoriasis, and nail lichen planus. Retronychia is associated with increased disorganized polymorphic capillaries compared with controls and onychomycosis.
Limitations: Limitations include a small sample size for certain nail conditions and small numbers of nail psoriasis patients with psoriatic arthritis.
Conclusion: Our findings highlight nailfold capillaroscopy as a potentially quick, cost-effective, and noninvasive imaging modality, as an adjunct for diagnosis and treatment initiation for patients with onychodystrophies.
Competing Interests: Conflicts of interest Dr Lipner has served as a consultant for Eli Lilly, Ortho-Dermatologics, BelleTorus Corporation, and Moberg Pharmaceuticals. Drs Hwang and Miller have no conflicts of interest to declare.
(Copyright © 2024 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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