Mechanistic Insights and Knowledge Gaps in the Effects of Radiation Therapy on Cardiac Arrhythmias.

Autor:	Balaji P; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia., Liulu X; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia., Sivakumar S; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia., Chong JJH; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Centre for Heart Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia., Kizana E; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Centre for Heart Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia., Vandenberg JI; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia., Hill AP; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia., Hau E; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Translational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia; Department of Radiation Oncology, Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, New South Wales, Australia; Blacktown Hematology and Cancer Centre, Blacktown Hospital, Blacktown, New South Wales, Australia., Qian PC; Cardiology Department, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia; Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia. Electronic address: pierre.qian@sydney.edu.au.
Jazyk:	angličtina
Zdroj:	International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2025 Jan 01; Vol. 121 (1), pp. 75-89. Date of Electronic Publication: 2024 Sep 01.
DOI:	10.1016/j.ijrobp.2024.08.040
Abstrakt:	Stereotactic body radiation therapy (SBRT) is an innovative modality for the treatment of refractory ventricular arrhythmias (VAs). Phase 1/2 clinical trials have demonstrated the remarkable efficacy of SBRT at reducing VA burden (by >85%) in patients with good short-term safety. SBRT as an option for VA treatment delivered in an ambulatory nonsedated patient in a single fraction during an outpatient session of 15 to 30 minutes, without added risks of anesthetic or surgery, is clinically relevant. However, the underlying mechanism remains unclear. Currently, the clinical dosing of SBRT has been derived from preclinical studies aimed at inducing transmural fibrosis in the atria. The propitious clinical effects of SBRT appear earlier than the time course for fibrosis. This review addresses the plausible mechanisms by which radiation alters the electrophysiological properties of myocytes and myocardial conduction to impart an antiarrhythmic effect, elucidate clinical observations, and point the direction for further research in this promising area. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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