ASTCT and USCLC Clinical Practice Recommendations for Allogeneic Stem Cell Transplant in Mycosis Fungoides and Sézary Syndrome.

Autor: Goyal A; Department of Dermatology, University of Minnesota, Minneapolis, Minnesota. Electronic address: Goyal046@umn.edu., O'Leary D; Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota., Dabaja B; Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Weng WK; Blood and Marrow Transplantation, and Cellular Therapy, Department of Medicine, Stanford University, Stanford, California., Zain J; Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California., Cutler C; Division of Transplantation and Cellular Therapy, Dana-Farber Cancer Institute, Boston, Massachusetts., Guitart J; Department of Dermatology, Northwestern Feinberg School of Medicine, Evanston, Illinois., Kim YH; Departments of Dermatology and Medicine/Division of Oncology, Stanford University, Stanford, California., Geskin LJ; Department of Dermatology, Columbia University, New York, New York., Hoppe RT; Department of Radiation Oncology, Stanford University, Stanford, California., Wilson LD; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut., Beaven AW; Division of Hematology, University of North Carolina, Chapel Hill, North Carolina., Horwitz S; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, New York., Allen PB; Department of Hematology & Medical Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia., Barta SK; Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania., Bohjanen K; Department of Dermatology, University of Minnesota, Minneapolis, Minnesota., Brammer JE; Division of Hematology, Ohio State University James Comprehensive Cancer Center, Columbus, Ohio., Carter JB; Department of Dermatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire., Comfere N; Departments of Dermatology and Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota., DeSimone JA; Department of Dermatology, University of Virginia Schar Cancer Institute, Fairfax, Virginia., Dusenbery K; Department of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota., Duvic M; Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas., Huen A; Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas., Jagadeesh D; Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio., Kelsey CR; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina., Khodadoust MS; Division of Oncology, Department of Medicine, Stanford University, Stanford, California., Lechowicz MJ; Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia., Mehta-Shah N; Department of Medicine, Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri., Moskowitz AJ; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, New York., Olsen EA; Departments of Dermatology and Medicine, Duke University Medical Center, Durham, North Carolina., Poh C; Division of Hematology and Oncology, University of Washington, Seattle, Washington., Pro B; Department of Hematology and Oncology, New York Presbyterian - Columbia University Irving Medical Center, New York, New York., Querfeld C; Department of Pathology, Division of Dermatology & Beckman Research Institute, City of Hope National Medical Center, Duarte, California., Sauter C; Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio., Sokol L; Malignant Hematology, Moffitt Cancer Center, Tampa, Florida., Sokumbi O; Departments of Dermatology and Laboratory Medicine & Pathology, Mayo Clinic, Jacksonville, Florida., Wilcox RA; Division of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan., Zic JA; Department of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee., Hamadani M; Division of Hematology & Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin., Foss F; Department of Hematology/Oncology, Yale University School of Medicine, New Haven, Connecticut.
Jazyk: angličtina
Zdroj: Transplantation and cellular therapy [Transplant Cell Ther] 2024 Nov; Vol. 30 (11), pp. 1047-1060. Date of Electronic Publication: 2024 Sep 01.
DOI: 10.1016/j.jtct.2024.08.020
Abstrakt: Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphoma (CTCL). While MF generally follows an indolent course, a subset of patients will experience progressive and/or treatment-refractory disease; Sézary syndrome is an aggressive lymphoma associated with high morbidity and mortality. Although allogeneic hematopoietic cell transplant (allo-HCT) is the only currently available potentially curative treatment modality for MF/SS there is no published guidance on referral criteria, transplant timing orallo-HCT approach. To develop consensus clinical practice recommendations, we performed a Delphi survey of 32 specialists in dermatology (n = 9), transplant hematology/oncology (n = 10), non-transplant hematology/oncology (n = 8), and radiation oncology (n = 5) from across the United States. Consensus required agreement of ≥75% of participants. Sixteen consensus statements were generated on four topics: (1) criteria for referral for consideration for allo-HCT, (2) allo-HCT preparative regimens and procedures (3) disease status at the time of allo-HCT, and (4) multidisciplinary management in the pre- and post-transplant settings. These clinical practice guidelines provide a framework for decision-making regarding allo-HCT for MF/SS and highlight areas for future prospective investigation.
(Copyright © 2024 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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