Relationship between fresh single embryo morphology scores and serum HCG values at 14 days and 14-18-day doubling values.

Autor: Chu J; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Guan S; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Ma R; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Zhang X; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Ning S; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Song W; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Yao G; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Shi S; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China., Jin H; Centre for Reproductive Medicine of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.. Electronic address: jinhx@zzu.edu.cn.
Jazyk: angličtina
Zdroj: Reproductive biomedicine online [Reprod Biomed Online] 2024 Nov; Vol. 49 (5), pp. 104325. Date of Electronic Publication: 2024 Jun 22.
DOI: 10.1016/j.rbmo.2024.104325
Abstrakt: Research Question: What is the effect of embryo morphology score on 14-day β-HCG levels and 14-18-day β-HCG doubling values, and do they have differences in day-3 embryo or day-5 blastocyst transfers?
Design: Retrospective analysis of 4434 fresh cycles of single embryo transfers (SET) with β-HCG ≥15 mIU/ml on day 14 after transfer via IVF and ICSI. The correlation between embryo morphology score and 14-day β-HCG was examined. Doubling of 14-18 day β-HCG was analysed in 2628 cycles to determine correlations with embryo morphology score.
Results: In day-3 SET, number of embryonic cells was positively correlated with 14-day post-transfer β-HCG values (R = 0.076; P = 0.013). No significant correlation was observed between the grade of the transferred embryos and the 14-18-day serum β-HCG doubling values. In day-5 single blastocyst transfers, the degree of blastocyst expansion, trophoblast cell and inner cell mass (ICM) grades demonstrated a significant positive correlation with 14-day post-transfer β-HCG (P < 0.001, P = 0.014, P = 0.003). Degree of blastocyst expansion was significantly correlated with 14-18-day β-HCG doubling values (R = -0.051, P = 0.027). Grades of the ICM and trophoblast cells showed no significant correlation with 14-18-day β-HCG doubling values.
Conclusion: In fresh SET, embryo morphology score influences 14-day β-HCG values in day-3 embryos and day-5 blastocyst transfers. Embryo morphology score in day-3 SET does not affect 14-18-day β-HCG doubling values. Degree of blastocyst expansion significantly affects 14-18-day β-HCG doubling values in day-5 blastocyst transfers.
(Copyright © 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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