Potential for tumor aggressiveness and its association with vasculogenic mimicry marker in colorectal carcinomas in Indian population- A tertiary care hospital level study.
| Autor: | Walia GK; Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India., Kinra P; Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India., Akal RS; Department of Medicine, Command Hospital Airforce, Bengaluru, Karnataka, India. |
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| Jazyk: | angličtina |
| Zdroj: | Indian journal of pathology & microbiology [Indian J Pathol Microbiol] 2024 Sep 02. Date of Electronic Publication: 2024 Sep 02. |
| DOI: | 10.4103/ijpm.ijpm_792_23 |
| Abstrakt: | Background: Vasculogenic mimicry (VM) is the ability of cancer stem cells of aggressive phenotype to mimic embryonic vascular network by forming channels lined by tumor cells, thereby, promoting tumor growth. These channels are periodic acid-schiff positive and CD34 negative and have been associated with tumor invasion, metastasis, and poor prognosis. It is a promising target for developing novel anticancer therapeutics and contributes to personalized medicine. Aim: Our study aims to look for an association of vasculogenic mimicry marker (VMM) with the aggressiveness of colorectal carcinomas (CRCs). Settings and Design: All retrospective and prospective cases of colorectal adenocarcinomas received over period of five years, from 2017 to 2021 were included in this study and a case-control study was planned. Materials and Methods: The study population was divided into two comparison groups based on TNM staging (a) those with non-aggressive tumors (controls; TNM stage I and II) and (b) those with aggressive tumors (cases; TNM stage III and IV). A total of 36 controls and 27 cases were studied. Hematoxylin and eosin stain, PAS, and CD34 immunohistochemistry were conducted. PAS positivity with negative CD34 in the same case was designated as VMM positive. VMM status was correlated with tumor stage, grade, and other pathological markers of prognosis. Statistical Analysis: The Chi-square test was used to find an association between the aggressiveness of CRCs and VM positivity. The P value < 0.05 was considered to be significant. Results: It was found that VMM was significantly associated with the aggressiveness of CRCs. Conclusion: VMM is a promising marker for its clinical utility in day-to-day routine IHC studies and its positivity correlates with tumor aggressiveness. (Copyright © 2024 Copyright: © 2024 Indian Journal of Pathology and Microbiology.) |
| Databáze: | MEDLINE |
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