| Autor: |
Malay S; Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla, Himachal Pradesh. drsarkarmalay23@rediffmail.com., Madabhavi IV; Department of Medical and Pediatric Oncology, J N Medical College; KLE Academy of Higher Education and Research (KAHER), Belagavi; Kerudi Cancer Hospital, Bagalkot, Karnataka. irappamadabhavi@gmail.com., Tripathi A; Department of Pulmonary and Critical Care Medicine, King George's Medical University, Lucknow. drsarkarmalay23@rediffmail.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace [Monaldi Arch Chest Dis] 2024 Aug 30. Date of Electronic Publication: 2024 Aug 30. |
| DOI: |
10.4081/monaldi.2024.2981 |
| Abstrakt: |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded, positive-sense RNA virus. The SARS-CoV-2 virus is evolving continuously, and many variants have been detected over the last few years. SARS-CoV-2, as an RNA virus, is more prone to mutating. The continuous evolution of the SARS-CoV-2 virus is due to genetic mutation and recombination during the genomic replication process. Recombination is a naturally occurring phenomenon in which two distinct viral lineages simultaneously infect the same cellular entity in an individual. The evolution rate depends on the rate of mutation. The rate of mutation is variable among the RNA viruses, with the SARS-CoV-2 virus exhibiting a lower rate of mutation than other RNA viruses. The novel 3'-to-5' exoribonuclease proofreading machinery is responsible for a lower rate of mutation. Infection due to the SARS-CoV-2, influenza, and respiratory syncytial virus has been reported from around the world during the same period of fall and winter, resulting in a "tripledemic." The JN.1 variant, which evolved from the predecessor, the omicron variant BA.2.86, is currently the most dominant globally. The impact of the JN.1 variant on transmissibility, disease severity, immune evasion, and diagnostic and therapeutic escape will be discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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