| Autor: |
Kooner HK; Robarts Research Institute, Western University, London, Canada.; Department of Medical Biophysics, Western University, London, Canada., Wyszkiewicz PV; Robarts Research Institute, Western University, London, Canada.; Department of Medical Biophysics, Western University, London, Canada., Matheson AM; Robarts Research Institute, Western University, London, Canada.; Department of Medical Biophysics, Western University, London, Canada., McIntosh MJ; Robarts Research Institute, Western University, London, Canada.; Department of Medical Biophysics, Western University, London, Canada., Abdelrazek M; Department of Medical Imaging, Western University, London, Canada., Dhaliwal I; Division of Respirology, Department of Medicine, Western University, London, Canada., Nicholson JM; Division of Respirology, Department of Medicine, Western University, London, Canada., Kirby M; Department of Physics, Toronto Metropolitan University, Toronto, Canada., Svenningsen S; Division of Respirology, Department of Medicine, McMaster University and Firestone Institute for Respiratory Health, St Joseph's Health Care, Hamilton, Canada., Parraga G; Robarts Research Institute, Western University, London, Canada.; Department of Medical Biophysics, Western University, London, Canada.; Department of Medical Imaging, Western University, London, Canada.; Division of Respirology, Department of Medicine, Western University, London, Canada. |
| Abstrakt: |
Chest CT provides a way to quantify pulmonary airway and vascular tree measurements. In patients with COPD, CT airway measurement differences in females are concomitant with worse quality-of-life and other outcomes. CT total airway count (TAC), airway lumen area (LA), and wall thickness (WT) also differ in females with long-COVID. Our objective was to evaluate CT airway and pulmonary vascular and quality-of-life measurements in females with COPD as compared to ex-smokers and patients with long-COVID. Chest CT was acquired 3-months post-COVID-19 infection in females with long-COVID for comparison with the same inspiratory CT in female ex-smokers and COPD patients. TAC, LA, WT, and pulmonary vascular measurements were quantified. Linear regression models were adjusted for confounders including age, height, body-mass-index, lung volume, pack-years and asthma diagnosis. Twenty-one females (53 ± 14 years) with long-COVID, 17 female ex-smokers (69 ± 9 years) and 13 female COPD (67 ± 6 years) patients were evaluated. In the absence of differences in quality-of-life scores, females with long-COVID reported significantly different LA ( p = 0.006) compared to ex-smokers but not COPD ( p = 0.7); WT% was also different compared to COPD ( p = 0.009) but not ex-smokers ( p = 0.5). In addition, there was significantly greater pulmonary small vessel volume (BV 5 ) in long-COVID as compared to female ex-smokers ( p = 0.045) and COPD ( p = 0.003) patients and different large (BV 10 ) vessel volume as compared to COPD ( p = 0.03). In females with long-COVID and highly abnormal quality-of-life scores, there was CT evidence of airway remodelling, similar to ex-smokers and patients with COPD, but there was no evidence of pulmonary vascular remodelling. Clinical Trial Registration: www.clinicaltrials.gov NCT05014516 and NCT02279329. |
