Levels of biomarkers associated with subconcussive head hits in mixed martial arts fighters.
| Autor: | de Lima Filho NM; Department of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil., Fernandes SGG; Department of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil., Costa V; Health Science Center, Postgraduate Program in Drug Development and Technological Innovation, Federal University of Rio Grande do Norte, Natal, Brazil., Araujo D; Health Sciences College of Trairi, Federal University of Rio Grande do Norte, Santa Cruz, Brazil., Godeiro C Jr; Department of Integrated Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Guerra G; Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil., Guerra RO; Department of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil., Ribeiro KF; Department of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | PeerJ [PeerJ] 2024 Aug 28; Vol. 12, pp. e17752. Date of Electronic Publication: 2024 Aug 28 (Print Publication: 2024). |
| DOI: | 10.7717/peerj.17752 |
| Abstrakt: | Background: Concussion and the damage resulting from this event related to brain function have been widely studied; however, little is known about subconcussive impacts, especially in Mixed Martial Arts (MMA) fighters, which is a combat and full contact sport in which most blows are aimed at the head. Objective: This study aims to evaluate the biomarker levels associated with subconcussive hits to the head in MMA fighters. Methods: This is an exploratory study in which 30 male subjects (10 MMA fighters, 10 healthy individuals who practice muscle training, and 10 healthy sedentary individuals) aged between 18 and 32 years (25.4 ± 3.8) were evaluated. These individuals underwent blood collection to assess their Ubiquitin C-terminal hydrolase (UCH-L1), Glial Fibrillary Acidic Protein (GFAP) and Brain Derived Neurotrophic Factor (BDNF) levels before, immediately after and 72 hours after the sparring session (for the fighters) and were compared between groups. Results: Significant differences were found at baseline between active and healthy fighters in BDNF levels ( p = 0.03). A significant reduction of BDNF levels were also observed between the post-immediate and 72h after the sparring session ( p = 0.03). No differences were observed in the number or severity of symptoms reported by the fighters. Conclusion: Despite the exploratory approach, the findings of this study may help to understand the influence of repeated subconcussive hits to the head in MMA fighters, as well as to propose preventive interventions which can minimize the effects of the impact of hits, preserving fighters' neuronal integrity and function. Competing Interests: The authors declare there are no competing interests. (©2024 de Lima Filho et al.) |
| Databáze: | MEDLINE |
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