Virucidal activity of porphyrin-based metal-organic frameworks against highly pathogenic coronaviruses and hepatitis C virus.

Autor: Plastiras OE; Unité de Catalyse et Chimie du Solide (UCCS), Univ. Lille, CNRS, Centrale Lille, Univ. Artois, F-59000, Lille, France.; U1019, UMR 9017, CIIL - Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, CNRS, INSERM, CHU de Lille, 59000, Lille, France., Bouquet P; Clinical Microbiology Unit, Institut Pasteur de Lille, Lille, F-59000, France., Raczkiewicz I; U1019, UMR 9017, CIIL - Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, CNRS, INSERM, CHU de Lille, 59000, Lille, France., Belouzard S; U1019, UMR 9017, CIIL - Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, CNRS, INSERM, CHU de Lille, 59000, Lille, France., Martin De Fourchambault E; U1019, UMR 9017, CIIL - Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, CNRS, INSERM, CHU de Lille, 59000, Lille, France., Dhainaut J; Unité de Catalyse et Chimie du Solide (UCCS), Univ. Lille, CNRS, Centrale Lille, Univ. Artois, F-59000, Lille, France., Dacquin JP; Unité de Catalyse et Chimie du Solide (UCCS), Univ. Lille, CNRS, Centrale Lille, Univ. Artois, F-59000, Lille, France., Goffard A; U1019, UMR 9017, CIIL - Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, CNRS, INSERM, CHU de Lille, 59000, Lille, France., Volkringer C; Unité de Catalyse et Chimie du Solide (UCCS), Univ. Lille, CNRS, Centrale Lille, Univ. Artois, F-59000, Lille, France.
Jazyk: angličtina
Zdroj: Materials today. Bio [Mater Today Bio] 2024 Aug 02; Vol. 28, pp. 101165. Date of Electronic Publication: 2024 Aug 02 (Print Publication: 2024).
DOI: 10.1016/j.mtbio.2024.101165
Abstrakt: The antiviral effect of four porphyrin-based Metal-Organic Frameworks (PMOFs) with Al and Zr, namely Al-TCPP, PCN-222, PCN-223 and PCN-224 was assessed for the first time against HCoV-229E, two highly pathogenic coronaviruses (SARS-CoV-2 and MERS-CoV) and hepatitis C virus (HCV). Infection tests in vitro were done under dark or light exposure for different contact times, and it was found that 15 min of light exposure were enough to give antiviral properties to the materials, therefore inactivating HCoV-229E by 99.98 % and 99.96 % for Al-TCPP and PCN-222. Al-TCPP diminished the viral titer of SARS-CoV-2 greater than PCN-222 in the same duration of light exposure, having an effect of 99.95 % and 93.48 % respectively. Next, Al-TCPP was chosen as the best candidate possessing antiviral properties and was tested against MERS-CoV and HCV, showcasing a reduction of infectivity of 99.28 % and 98.15 % respectively for each virus. The mechanism of the antiviral activity of the four PMOFs was found to be the production of singlet oxygen 1 O 2 from the porphyrin ligand TCPP when exposed to visible light, by using sodium azide (NaN 3 ) as a scavenger, that can later attack the phospholipids on the envelope of the viruses, thus preventing their entry into the cells.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)
Databáze: MEDLINE
Externí odkaz: