Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review.

Autor:	Belay WY; Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Getachew M; Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Tegegne BA; Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Teffera ZH; Department of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Dagne A; Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Zeleke TK; Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Abebe RB; Department of clinical pharmacy, College of medicine and health sciences, University of Gondar, Gondar, Ethiopia., Gedif AA; Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Fenta A; Department of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Yirdaw G; Department of environmental health science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Tilahun A; Department of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia., Aschale Y; Department of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2024 Aug 16; Vol. 15, pp. 1444781. Date of Electronic Publication: 2024 Aug 16 (Print Publication: 2024).
DOI:	10.3389/fphar.2024.1444781
Abstrakt:	Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability to effectively treat bacterial infections. This review aims to provide a comprehensive overview of the types and mechanisms of antibacterial drug resistance. To achieve this aim, a thorough literature search was conducted to identify key studies and reviews on antibacterial resistance mechanisms, strategies and next-generation antimicrobials to contain antimicrobial resistance. In this review, types of resistance and major mechanisms of antibacterial resistance with examples including target site modifications, decreased influx, increased efflux pumps, and enzymatic inactivation of antibacterials has been discussed. Moreover, biofilm formation, and horizontal gene transfer methods has also been included. Furthermore, measures (interventions) taken to control antimicrobial resistance and next-generation antimicrobials have been discussed in detail. Overall, this review provides valuable insights into the diverse mechanisms employed by bacteria to resist the effects of antibacterial drugs, with the aim of informing future research and guiding antimicrobial stewardship efforts. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Belay, Getachew, Tegegne, Teffera, Dagne, Zeleke, Abebe, Gedif, Fenta, Yirdaw, Tilahun and Aschale.)
Databáze:	MEDLINE
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