Blood cell counts and nonalcoholic fatty liver disease: Evidence from Mendelian randomization analysis.

Autor:	Hu B; Department of Laboratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China., Wan AH; Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China., Xiang XQ; Department of Positron Emission Tomography-Computed Tomography Imaging Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China., Wei YH; Department of School of Public Health, Harbin Medical University, Harbin 150081, Heilongjiang Province, China., Chen Y; Department of Positron Emission Tomography-Computed Tomography Imaging Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China., Tang Z; Department of Positron Emission Tomography-Computed Tomography Imaging Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China., Xu CD; Department of Positron Emission Tomography-Computed Tomography Imaging Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China., Zheng ZW; Department of Cardiovascular Ultrasound Medicine Center, Shanghai Eighth People's Hospital, Shanghai 200235, China., Yang SL; Department of Cardiovascular Ultrasound Medicine Center, Shanghai Eighth People's Hospital, Shanghai 200235, China., Zhao K; Department of Positron Emission Tomography-Computed Tomography Imaging Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China. zzleaning@163.com.
Jazyk:	angličtina
Zdroj:	World journal of hepatology [World J Hepatol] 2024 Aug 27; Vol. 16 (8), pp. 1145-1155.
DOI:	10.4254/wjh.v16.i8.1145
Abstrakt:	Background: Previous research has highlighted correlations between blood cell counts and chronic liver disease. Nonetheless, the causal relationships remain unknown. Aim: To evaluate the causal effect of blood cell traits on liver enzymes and nonalcoholic fatty liver disease (NAFLD) risk. Methods: Independent genetic variants strongly associated with blood cell traits were extracted from a genome-wide association study (GWAS) conducted by the Blood Cell Consortium. Summary-level data for liver enzymes were obtained from the United Kingdom Biobank. NAFLD data were obtained from a GWAS meta-analysis (8434 cases and 770180 controls, discovery dataset) and the Fingen GWAS (2275 cases and 372727 controls, replication dataset). This analysis was conducted using the inverse-variance weighted method, followed by various sensitivity analyses. Results: One SD increase in the genetically predicted haemoglobin concentration (HGB) was associated with a β of 0.0078 (95%CI: 0.0059-0.0096), 0.0108 (95%CI: 0.0080-0.0136), 0.0361 (95%CI: 0.0156-0.0567), and 0.0083 (95%CI: 00046-0.0121) for alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase, and gamma-glutamyl transferase, respectively. Genetically predicted haematocrit was associated with ALP (β = 0.0078, 95%CI: 0.0052-0.0104) and ALT (β = 0.0057, 95%CI: 0.0039-0.0075). Genetically determined HGB and the reticulocyte fraction of red blood cells increased the risk of NAFLD [odds ratio (OR) = 1.199, 95%CI: 1.087-1.322] and (OR = 1.157, 95%CI: 1.071-1.250). The results of the sensitivity analyses remained significant. Conclusion: Novel causal blood cell traits related to liver enzymes and NAFLD development were revealed through Mendelian randomization analysis, which may facilitate the diagnosis and prevention of NAFLD. Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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