GC-MS analysis and nutra-pharmaceutical potential of Mentha piperita essential oil extracted by supercritical fluid extraction and hydro-distillation.

Autor: Abbas A; Institute of Chemistry, University of Sargodha, Sargodha, 41000, Pakistan.; Department of Chemistry, Govt. Islamia Graduate College, Chiniot, Pakistan., Anwar F; Institute of Chemistry, University of Sargodha, Sargodha, 41000, Pakistan.; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia., Ahmad N; Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan., Rehman AT; Institute of Molecular Biology and Biotechnology, University of Lahore, Sargodha Campus, Sargodha, Pakistan., Mohammed OA; Department of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia., Abdel-Reheim MA; Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef 62521, Egypt., Iqbal M; School of Chemistry, University of the Punjab, Lahore, Pakistan., Iqbal S; Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan., Nazir A; Department of Chemistry, The University of Lahore, Lahore, Pakistan.
Jazyk: angličtina
Zdroj: Heliyon [Heliyon] 2024 Jul 26; Vol. 10 (16), pp. e35282. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).
DOI: 10.1016/j.heliyon.2024.e35282
Abstrakt: This study reports the comparative evaluation of yield, physico-chemical composition and biological attributes (antioxidant activity, antimicrobial activity, biofilm inhibition and hemolytic activity) of peppermint ( Mentha piperita L.) essential oil (EO) obtained by hydro-distillation (HD) and supercritical fluid (CO 2 ) extraction (SCFE) methods. The yield (%) of EO obtained by HD (0.20 %) was significantly ( p  < 0.05) higher than that of SCFE (0.13 %) while the variation in the physical parameters like solubility, color, density (at 25 °C) and refractive index (at 25 °C) was not significant between the tested oils. The data of chemical compositional analysis revealed that menthol was the key component in the EO obtained by HD (52.85 %) and SCFE (45.51 %), followed by menthone [HD (25.93 %) and SCFE (27.3 %)] and eucalyptol [HD (8.59 %); SCFE (8.92 %)]. The EO extracted with supercritical fluid (SCFE-EO) exhibited superior ( p  < 0.05) DPPH free radical inhibition potential (52 %) with an IC 50 value of 15.65 μg/mL and reducing power compared to that of HD-EO. The highest antimicrobial activity was exhibited by SCFE-EO against Pasturella multocida with an inhibition zone of 18.00 mm (MIC value of 86 μg/mL). The results of biofilm inhibition and hemolytic activity revealed that the SCFE method was superior to recover high quality EO in comparison to the HD method. The peppermint EO obtained by SCFE, owing to potent bioactive components, can be a potential candidate to develop nutra-pharmaceuticals.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)
Databáze: MEDLINE
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