Primary central nervous system lymphoma: A diagnostic challenge in a young immunocompetent patient with limited resources.

Autor:	Ayalew ZS; Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Gebregiorgis M; Division of Hematology, Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Azibte GT; Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Hamza AK; Department of Pathology, Addis Ababa University, Addis Ababa, Ethiopia., Abdo IS; Department of Pathology, Addis Ababa University, Addis Ababa, Ethiopia., Molla BA; Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Jazyk:	angličtina
Zdroj:	Radiology case reports [Radiol Case Rep] 2024 Aug 07; Vol. 19 (10), pp. 4644-4649. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).
DOI:	10.1016/j.radcr.2024.07.039
Abstrakt:	Primary central nervous system lymphoma is a rare form of central nervous system malignancy. It predominantly affects immunocompromised individuals and the elderly population. Diffuse large B-cell lymphoma is the most common type. This case report presents a 35-year-old female patient presented with progressive difficulty maintaining balance, headaches, seizures, and blurry vision for 2 months. Physical examination was unremarkable except for sluggish bilateral pupillary reaction and lower extremity weakness. MRI revealed multiple bilateral intraaxial masses. Biopsy and immunohistochemistry confirmed diffuse large B-cell lymphoma, nongerminal center B-cell type. However, the diagnosis was delayed for 4 months. The delay in the diagnosis was caused by its atypical presentation, a surgical site infection, and limited resources, which led the patient to disregard the recommended treatment and leave the hospital against medical advice. Even in the absence of risk factors of primary central nervous system lymphoma, it should be considered as a differential in a young patient with neurologic symptoms and intraaxial mass. Minimally invasive biopsy techniques and readily available immunohistochemistry are essential for prompt diagnosis and guiding treatment. (© 2024 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
Databáze:	MEDLINE
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