A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995-2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches.

Autor:	De NV; Ha Noi Medical University, 01 Ton That Tung, Ha Noi, Viet Nam., Minh PN; Ha Noi Medical University, 01 Ton That Tung, Ha Noi, Viet Nam., Le TH; Institute of Biotechnology, 18 Hoang Quoc Viet, Ha Noi, Viet Nam., Dung DT; National Institute of Malariology, Parasitology and Entomology, Ha Noi, Viet Nam., Duong TT; National Institute of Malariology, Parasitology and Entomology, Ha Noi, Viet Nam., Tuan BV; Quy Nhon Institute of Malariology, Parasitology and Entomology, Quy Nhon, Viet Nam., Dong LT; Ho Chi Minh Institute of Malariology, Parasitology and Entomology, Ho Chi Minh, Viet Nam., Chau NVV; Ho Chi Minh Hospital of Tropical Diseases, Ho Chi Minh City, Viet Nam., Cuervo PF; Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain., Bargues MD; Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain., Valero MA; Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain., Gabrielli AF; Global Neglected Tropical Diseases Programme (NTD), World Health Organization, Avenue Appia 20, CH-1211 Geneva 27, Switzerland., Montresor A; Global Neglected Tropical Diseases Programme (NTD), World Health Organization, Avenue Appia 20, CH-1211 Geneva 27, Switzerland., Mas-Coma S; Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	One health (Amsterdam, Netherlands) [One Health] 2024 Aug 03; Vol. 19, pp. 100869. Date of Electronic Publication: 2024 Aug 03 (Print Publication: 2024).
DOI:	10.1016/j.onehlt.2024.100869
Abstrakt:	Fascioliasis, only foodborne trematodiasis of worldwide distribution, is caused by Fasciola hepatica and F. gigantica , liver flukes transmitted by freshwater snails. Southern and southeastern Asia is an emerging hot spot of F. gigantica , despite its hitherto less involvement in human infection. In Vietnam, increasing cases have been reported since 1995, whereas only sixteen throughout 1800-1994. A database was created to include epidemiological data of fascioliasis patients from the 63 Vietnam provinces throughout 1995-2019. Case profiles were based on serology, symptoms, eosinophilia, imaging techniques, stool egg finding, and post-specific-treatment recovery. Radio broadcasting about symptoms and costless diagnosis/treatment led patients to hospitals after symptom onset. Yearly case numbers were modelled and spatio-temporally analyzed. Missing data and confounders were assessed. The countrywide spread has no precedent. It started in the central coast, including 53,109 patients, mostly adults and females. Seasonality, linked to vegetable consumption, peaks in June, although the intensity of this peak differs according to relief/climatic zones. Incidence data and logistic regression curves are obtained for the first time in human fascioliasis. Fasciolid hybrids accompanying the spreading F. gigantica flukes, and climate change assessed by risk index correlations, are both ruled out as outbreak causes. Human-guided movements of livestock from an original area prove to be the way used by fasciolids and lymnaeid vectors to expand geographically. Radix viridis , a highly efficient transmitting and colonizing vector, played a decisive role in the spread. The use of irrigated crop fields, widely inhabited by R. viridis , for livestock grazing facilitated the transmission and spread of the disease. General physician awareness and diagnostic capacity improvement proved the successful impact of such knowledge transfer in facilitating and increasing patient infection detection. Information, education and communication to the public by radio broadcasting demonstrated to be very helpful. Fasciola gigantica is able to cause epidemic and endemic situations similar to F. hepatica . The magnitude of the human outbreak in Vietnam is a health wake-up call for southern and southeastern countries of Asia which present the highest human population densities with increasing food demands, uncontrolled livestock inter-country exchange, foreign import practices, and monsoon's increasing climate change impact. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 Published by Elsevier B.V.)
Databáze:	MEDLINE
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