Natural recovery of cardiac allograft diastolic function, a retrospective longitudinal report.
| Autor: | Fu S; College of Medicine, University of Florida, Gainesville, FL, United States of America., Patel AGM; College of Medicine, University of Florida, Gainesville, FL, United States of America.; Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, United States of America., Ruzieh M; Division of cardiovascular medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of America., Hanayneh S; College of Medicine, University of Florida, Gainesville, FL, United States of America., Vilaro J; Division of cardiovascular medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of America., Ahmed MM; Division of cardiovascular medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of America., Aranda JM Jr; Division of cardiovascular medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of America., Parker AM; Division of cardiovascular medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of America., Bleiweis MS; Congenital heart center, University of Florida, Gainesville, FL, United States of America., Jacobs JP; Congenital heart center, University of Florida, Gainesville, FL, United States of America., Al-Ani MA; Division of cardiovascular medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of America.; Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, United States of America. |
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| Jazyk: | angličtina |
| Zdroj: | American heart journal plus : cardiology research and practice [Am Heart J Plus] 2024 Jul 27; Vol. 45, pp. 100428. Date of Electronic Publication: 2024 Jul 27 (Print Publication: 2024). |
| DOI: | 10.1016/j.ahjo.2024.100428 |
| Abstrakt: | Cardiac allografts suffer diastolic dysfunction early post-heart transplantation (HTx) due to ischemic injury, however the natural course of diastology recovery post HTx remains unknown (Tallaj et al., 2007 [1]). We retrospectively reviewed 60 adult HTx patients between 2015 and 2021 at a single site. Invasive hemodynamics and echocardiograms were obtained at 2 weeks and 1, 3, 6, and 12 months post-HTx. RA strain by 2D feature tracking was compared to intracardiac pressure measurements. In all patients, we observed normalization of RV and RA filling pressures by post-operative week 12 and recovery of diastolic dysfunction by month 6. There was an inverse correlation between RV end-diastolic pressure and RA contractile ( r = -0.192, p < 0.05) and reservoir ( r = -0.128, p < 0.05) functions in the allograft. As the post-transplant care paradigm shifts away from invasive procedures, right atrial indices should be included in imaging-based allograft surveillance studies. Competing Interests: Mohammad Al-Ani receives research support from HHS | National Institutes of Health grant UL1TR001427, American Heart Association grant 24SCEFIA1253259, and Bristol Myers Squibb quality improvement grant 150208980. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Databáze: | MEDLINE |
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