Fungal Peptidomelanin: A Novel Biopolymer for the Chelation of Heavy Metals.

Autor:	Kolipakala RS; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Basu S; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Sarkar S; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Biju BM; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Salazar D; Ecology and Genetics Research Unit, University of Oulu, Oulu 90014, Finland., Reddy L; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Pradeep P; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Yuvapriya MK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Nath S; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Gall R; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Samprathi AH; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India.; Department of Biotechnology, Fergusson College (Autonomous), Pune 411004, India., Balaji H; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India., Koundinya EAB; Department of Biotechnology, Manipal Institute of Technology, Manipal University, Manipal 576104, India., Shetye A; Department of Microbiology, St. Xavier's College, Mumbai 400001, India., Nagarajan D; Department of Biotechnology, M.S. Ramaiah University of Applied Sciences, Bangalore 560054, India.; Department of Microbiology, St. Xavier's College, Mumbai 400001, India.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2024 Aug 07; Vol. 9 (34), pp. 36353-36370. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).
DOI:	10.1021/acsomega.4c03704
Abstrakt:	Melanin is an amorphous, highly heterogeneous polymer found across all kingdoms of life. Although the properties of melanin can greatly vary, most forms are insoluble and strongly absorb light, appearing dark brown to black. Here, we describe a water-soluble form of melanin (peptidomelanin) secreted by the spores of Aspergillus niger (strain: melanoliber) during germination. Peptidomelanin is composed of an insoluble L-DOPA core polymer that is solubilized via short, copolymerized heterogeneous peptide chains forming a "corona" with a mean amino acid length of 2.6 ± 2.3. Based on in vitro experiments, we propose a biochemical copolymerization mechanism involving the hydroxylation of tyrosynylated peptides. Peptidomelanin is capable of chelating heavy metals such as lead, mercury, and uranium (as uranyl) in large quantities. Preliminary data indicates that peptidomelanin may have applications for the remediation of heavy metals in situ , including in agricultural settings. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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