Prevalence analysis of Chagas disease by age group in an endemic region of Brazil: possible scenario of active vectorial transmission.

Autor:	Cruz DS; Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., Damasceno RF; Superintendência Regional de Saúde de Montes Claros. Secretaria de Estado de Saúde de Minas Gerais, Minas Gerais, Brasil., Leite SF; Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., Cardoso MD; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., Almeida DNM; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., de Souza AB; Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., de Jesus Santos AC; Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., Veira TM; Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., Ribeiro ALP; Hospital das Clínicas e Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Brasil., de Oliveira LC; Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brasil. Faculdade de Medicina., Sabino EC; Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brasil. Faculdade de Medicina., Haikal DS; Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., Ferreira AM; Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil., Molina I; Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil.; Fundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Laboratório de Triatomíneos e Epidemiologia da Doença de Chagas, Belo Horizonte, Minas Gerais, Brasil.
Jazyk:	angličtina
Zdroj:	IJID regions [IJID Reg] 2024 Jul 09; Vol. 12, pp. 100400. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).
DOI:	10.1016/j.ijregi.2024.100400
Abstrakt:	Objectives: Chagas disease (CD) is an infectious disease that predominantly affects poor and vulnerable populations. The last estimate conducted by the World Health Organization in Latin America regarding the prevalence of CD occurred more than 10 years ago. However, there is a scarcity of data assessing the magnitude of CD in populations residing in considered high-risk regions. Therefore, this study aimed to assess the seroprevalence of CD in an endemic region in Northern Minas Gerais through serologic screening. Methods: This is a prevalence study conducted in the municipalities of Catuti, Mato Verde, Mirabela, Montes Azul, and São Francisco, Minas Gerais, Brazil. Data collection occurred between December 2021 and December 2022, involving a questionnaire with closed-ended questions. The variables analyzed included serologic test results, stratified age groups, health indicators, and housing conditions. Results: Of the 2978 participants, 272 individuals (9.1%) tested positive for CD serology. In the age group of 4 to 14 years, 15 to 49 years, and 50 years or older, the prevalence of positive serology was 0.8% (95% confidence interval [CI] 0.16-1.43), 5.5% (95% CI 4.20-6.83), and 18.8% (95% CI 16.48-21.11), respectively. Among the participating municipalities, Mato Verde had the highest prevalence of positive serology for CD (17%). For participants aged 4 to 14 years with positive serology for CD, first-degree relatives were invited to undergo serologic testing. It was possible to collect samples from relatives of all participants in this age group. However, none of the relatives tested positive. Conclusion: This study identified a 9.1% prevalence of individuals affected by CD who were unaware of their condition. In addition, having infected children in the 4 to 14 age group with mothers with negative serology would rule out congenital transmission of the disease. Competing Interests: The authors have no competing interests to declare. (© 2024 The Authors.)
Databáze:	MEDLINE
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