Gastrointestinal Metastases From Lobular Breast Carcinoma: A Literature Review.

Autor:	Kioleoglou Z; Department of Surgery, Metaxa Cancer Hospital, Piraeus, CYP., Georgaki E; Second Department of Medicine, Medical School, Hippocratio General Hospital of Athens, National and Kapodistrian University of Athens, Athens, GRC., Koufopoulos N; Second Department of Pathology, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC., Kostek O; Department of Internal Medicine, Division of Medical Oncology, Sultan 1 Murad State Hospital, Edirne, TUR., Volakakis N; Oncology Unit, General Hospital of Athens Hippocrates, Athens, GRC., Dimitriadou A; Oncology Unit, General Hospital of Athens Hippocrates, Athens, GRC., Kokkali S; Second Department of Medicine, Medical School, Hippocratio General Hospital of Athens, National and Kapodistrian University of Athens, Athens, GRC.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 31; Vol. 16 (7), pp. e65852. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024).
DOI:	10.7759/cureus.65852
Abstrakt:	Invasive lobular carcinoma (ILC) represents a rare subtype of breast carcinoma, originating from the lobule. Unlike ductal carcinoma, ILC does not express E-cadherin and thus can metastasize to uncommon sites. We aimed to investigate the clinicopathological characteristics of the rare subgroup of ILC patients with gastrointestinal (GI) metastases. A PubMed search was undertaken using the terms "Lobular Breast Carcinoma" AND "Gastrointestinal Metastasis." We identified 169 cases, with metachronous GI metastatic disease being approximately twice as common as synchronous GI metastases. The median age at initial diagnosis was 56.7 years (24-88). The majority of patients were hormonal receptor-positive and only a small minority was HER2-positive. The appearance of a gastrointestinal lesion was often the mode of revelation of ILC. Differential diagnosis from primary gastrointestinal cancer is sometimes challenging, especially in the case of signet-ring cell carcinoma. The median time from breast cancer diagnosis to GI metastases was 6.5 years (0-33). Most common metastatic sites include the stomach, colon, and rectum, in order of decreasing frequency, whereas metastases were found in every part of the digestive tract. In conclusion, metastases of ILC can arise in the gastrointestinal tract and they should be managed similarly to metastatic breast cancer. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Kioleoglou et al.)
Databáze:	MEDLINE
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