Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review.

Autor: Golmohammadi M; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Zamanian MY; Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran., Al-Ani AM; Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq., Jabbar TL; College of pharmacy, Al- Ayen University, Nasiriyah, Iraq., Kareem AK; Biomedical Engineering Department, Al-Mustaqbal University College, Hillah, Iraq., Aghaei ZH; Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Tahernia H; Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran., Hjazi A; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia., Jissir SA; College of Nursing, Al-Bayan University, Baghdad, Iraq., Hakimizadeh E; Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Jazyk: angličtina
Zdroj: Animal models and experimental medicine [Animal Model Exp Med] 2024 Sep 02. Date of Electronic Publication: 2024 Sep 02.
DOI: 10.1002/ame2.12491
Abstrakt: Background: Breast cancer (BC) continues to be a significant global health issue, with a rising number of cases requiring ongoing research and innovation in treatment strategies. Curcumin (CUR), a natural compound derived from Curcuma longa, and similar compounds have shown potential in targeting the STAT3 signaling pathway, which plays a crucial role in BC progression.
Aims: The aim of this study was to investigate the effects of curcumin and its analogues on BC based on cellular and molecular mechanisms.
Materials & Methods: The literature search conducted for this study involved utilizing the Scopus, ScienceDirect, PubMed, and Google Scholar databases in order to identify pertinent articles.
Results: This narrative review explores the potential of CUR and similar compounds in inhibiting STAT3 activation, thereby suppressing the proliferation of cancer cells, inducing apoptosis, and inhibiting metastasis. The review demonstrates that CUR directly inhibits the phosphorylation of STAT3, preventing its movement into the nucleus and its ability to bind to DNA, thereby hindering the survival and proliferation of cancer cells. CUR also enhances the effectiveness of other therapeutic agents and modulates the tumor microenvironment by affecting tumor-associated macrophages (TAMs). CUR analogues, such as hydrazinocurcumin (HC), FLLL11, FLLL12, and GO-Y030, show improved bioavailability and potency in inhibiting STAT3, resulting in reduced cell proliferation and increased apoptosis.
Conclusion: CUR and its analogues hold promise as effective adjuvant treatments for BC by targeting the STAT3 signaling pathway. These compounds provide new insights into the mechanisms of action of CUR and its potential to enhance the effectiveness of BC therapies.
(© 2024 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.)
Databáze: MEDLINE
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