Design, synthesis, and antiproliferative activity of new indole/1,2,4-triazole/chalcone hybrids as EGFR and/or c-MET inhibitors.
Autor: | Mahmoud E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt., Abdelhamid D; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.; Raabe College of Pharmacy, Ohio Northern University, Ohio, USA., Youssif BGM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Gomaa HAM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia., Hayallah AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New-Assiut, Egypt., Abdel-Aziz M; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt. |
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Jazyk: | angličtina |
Zdroj: | Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Sep; Vol. 357 (9), pp. e2300562. Date of Electronic Publication: 2024 Jun 21. |
DOI: | 10.1002/ardp.202300562 |
Abstrakt: | A novel group of indolyl-1,2,4-triazole-chalcone hybrids was designed, synthesized, and assessed for their anticancer activity. The synthesized compounds exhibited significant antiproliferative activity. Compounds 9a and 9e exhibited significant cancer inhibition with GI (© 2024 The Author(s). Archiv der Pharmazie published by Wiley‐VCH GmbH on behalf of Deutsche Pharmazeutische Gesellschaft.) |
Databáze: | MEDLINE |
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