QRAGE-Simultaneous multiparametric quantitative MRI of water content, T 1 , T 2 *, and magnetic susceptibility at ultrahigh field strength.
Autor: | Zimmermann M; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany., Abbas Z; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany., Sommer Y; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany., Lewin A; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-11, Jülich, Germany., Ramkiran S; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany., Felder J; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany.; RWTH Aachen University, Aachen, Germany., Worthoff WA; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany., Oros-Peusquens AM; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany., Yun SD; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany., Shah NJ; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-4, Jülich, Germany.; Forschungszentrum Jülich, Institute of Neuroscience and Medicine-11, Jülich, Germany.; JARA-BRAIN-Translational Medicine, Aachen, Germany.; Department of Neurology, RWTH Aachen University, Aachen, Germany. |
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Jazyk: | angličtina |
Zdroj: | Magnetic resonance in medicine [Magn Reson Med] 2025 Jan; Vol. 93 (1), pp. 228-244. Date of Electronic Publication: 2024 Sep 01. |
DOI: | 10.1002/mrm.30272 |
Abstrakt: | Purpose: To introduce quantitative rapid gradient-echo (QRAGE), a novel approach for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T Methods: QRAGE leverages a newly developed multi-echo MPnRAGE sequence, facilitating the acquisition of 171 distinct contrast images across a range of TI and TE points. To maintain a short acquisition time, we introduce MIRAGE2, a novel model-based reconstruction method that exploits prior knowledge of temporal signal evolution, represented as damped complex exponentials. MIRAGE2 minimizes local Block-Hankel and Casorati matrices. Parameter maps are derived from the reconstructed contrast images through postprocessing steps. We validate QRAGE through extensive simulations, phantom studies, and in vivo experiments, demonstrating its capability for high-precision imaging. Results: In vivo brain measurements show the promising performance of QRAGE, with test-retest SDs and deviations from reference methods of < 0.8% for water content, < 17 ms for T Conclusion: QRAGE is a new, successful approach for simultaneously mapping multiple MR parameters at ultrahigh field. (© 2024 The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.) |
Databáze: | MEDLINE |
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