| Autor: |
Ko J; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea., Jang S; School of Life Science and Biotechnology, College of Natural Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea., Jang S; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea., Park S; Division of Animal Science, Gyeongsang National University, Jinju 52828; Institute of Agriculture and Life Science (IALS), Gyeongsang National University, Jinju 52828, Korea., Yi J; School of Animal Life Convergence Science, Hankyong National University, Anseong 17579, Korea., Choi DK; School of Life Science and Biotechnology, College of Natural Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea., Kim S; Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea., Kim MO; Department of Animal Science and Biotechnology, Kyungpook National University, Sangju 37224, Korea., Lim SG; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea., Ryoo ZY; School of Life Science and Biotechnology, College of Natural Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea. |
| Abstrakt: |
Glucose-dependent insulinotropic polypeptide (GIP), a 42-aminoacid hormone, exerts multifaceted effects in physiology, most notably in metabolism, obesity, and inflammation. Its significance extends to neuroprotection, promoting neuronal proliferation, maintaining physiological homeostasis, and inhibiting cell death, all of which play a crucial role in the context of neurodegenerative diseases. Through intricate signaling pathways involving its cognate receptor (GIPR), a member of the G protein-coupled receptors, GIP maintains cellular homeostasis and regulates a defense system against ferroptosis, an essential process in aging. Our study, utilizing GIP-overexpressing mice and in vitro cell model, elucidates the pivotal role of GIP in preserving neuronal integrity and combating age-related damage, primarily through the Epac/Rap1 pathway. These findings shed light on the potential of GIP as a therapeutic target for the pathogenesis of ferroptosis in neurodegenerative diseases and aging. [BMB Reports 2024; 57(9): 417-423]. |
