Review of Hydroxypropyl Methylcellulose in Artificial Tears for the Treatment of Dry Eye Disease.

Autor: Mysen OMB; Department of Ear, Nose and Throat, Østfold Hospital Trust, Kalnes, Moss, Norway., Hynnekleiv L; Department of Ophthalmology, Division of Head, Neck and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.; Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Hospital, London, UK.; Department of Computer Science, Oslo Metropolitan University, Oslo, Norway., Magnø MS; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.; Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Ophthalmology, Sørlandet Hospital Arendal, Arendal, Norway., Vehof J; Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Hospital, London, UK.; Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Dutch Dry Eye Clinic, Velp, Netherlands.; Department of Ophthalmology, Vestfold Hospital Trust, Tønsberg, Norway., Utheim TP; Department of Ophthalmology, Division of Head, Neck and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.; Department of Ophthalmology, Sørlandet Hospital Arendal, Arendal, Norway.; Department of Ophthalmology, Vestfold Hospital Trust, Tønsberg, Norway.; Department of Ophthalmology, Stavanger University Hospital, Oslo, Norway.; Department of Ophthalmology, Vestre Viken Hospital Trust, Drammen, Norway.; Department of Maxillofacial Surgery, Oslo University Hospital, Oslo, Norway.; Department of Research and Development, Oslo Metropolitan University, Oslo, Norway.; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway.; Department of Quality and Health Technology, The Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.; Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.; National Centre for Optics, Vision and Eye Care, Department of Optometry, Radiography and Lighting Design, Faculty of Health Sciences, University of South-Eastern Norway, Kongsberg, Norway.; Department of Health and Nursing Science, The Faculty of Health and Sport Sciences, University of Agder, Grimstad, Norway.; The Norwegian Dry Eye Clinic, Oslo, Norway.; Department of Ophthalmology, Faculty of Life Course Sciences and Medicine, King`s College London, London, UK.; Department of Ophthalmology, Østfold Hospital Trust, Moss, Norway.
Jazyk: angličtina
Zdroj: Acta ophthalmologica [Acta Ophthalmol] 2024 Dec; Vol. 102 (8), pp. 881-896. Date of Electronic Publication: 2024 Sep 01.
DOI: 10.1111/aos.16753
Abstrakt: Dry eye disease (DED) is a highly prevalent condition, resulting in reduced quality of life, lower participation in social life and impaired work efficiency. Hydroxypropyl methylcellulose (HPMC) is a cellulose-based viscosity-enhancing agent and is one of the most popular therapeutic ingredients in artificial tears. This review aims to evaluate the literature on the efficacy and safety of HPMC used in the treatment of DED. Literature searches were conducted in PubMed and Cochrane CENTRAL. A total of 28 clinical trials from 26 publications are included in this review, including 21 clinical intervention studies evaluating the effect of HPMC treatment over time and seven single instillation studies evaluating the short-term physical and symptomatic effects of HPMC after drop-instillation. The duration of clinical intervention studies ranged from 2 weeks to 5.5 months. DED severity ranged from mild to severe. Drop frequency ranged from two to up to 16 drops per day. HPMC concentration in artificial tears ranged from 0.2% to 0.5%. No major complications or adverse events were reported. Artificial tears containing HPMC were effective at improving symptoms and some signs of DED. However, combination drops with HPMC plus other therapeutic ingredients seem more effective than HPMC alone. HPMC appears to be equally effective or inferior to hyaluronic acid (HA). There is no evidence of superiority or inferiority to either carboxymethylcellulose (CMC) or polyethylene glycol 400/propylene glycol (PEG/PG). No single study explained the choice of drop frequency or HPMC concentration. More well-designed studies are needed to determine an evidence-based standard for HPMC treatment, including drop frequency, concentration and molecular weight for different DED severity and subgroups.
(© 2024 The Author(s). Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
Databáze: MEDLINE
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