Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness:Current Insights and Future Directions.

Autor: Marabitti V; Department of Biology, University of Rome Tor Vergata, Rome 00133, Italy., Vulpis E; Department of Biology, University of Rome Tor Vergata, Rome 00133, Italy., Nazio F; Department of Biology, University of Rome Tor Vergata, Rome 00133, Italy., Campello S; Department of Biology, University of Rome Tor Vergata, Rome 00133, Italy. Electronic address: silvia.campello@uniroma2.it.
Jazyk: angličtina
Zdroj: Pharmacological research [Pharmacol Res] 2024 Oct; Vol. 208, pp. 107382. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1016/j.phrs.2024.107382
Abstrakt: It is now recognized that tumors are not merely masses of transformed cells but are intricately interconnected with healthy cells in the tumor microenvironment (TME), forming complex and heterogeneous structures. Recent studies discovered that cancer cells can steal mitochondria from healthy cells to empower themselves, while reducing the functions of their target organ. Mitochondrial transfer, i.e. the intercellular movement of mitochondria, is recently emerging as a novel process in cancer biology, contributing to tumor growth, metastasis, and resistance to therapy by shaping the metabolic landscape of the tumor microenvironment. This review highlights the influence of transferred mitochondria on cancer bioenergetics, redox balance and apoptotic resistance, which collectively foster aggressive cancer phenotype. Furthermore, the therapeutic implications of mitochondrial transfer are discussed, emphasizing the potential of targeting these pathways to overcome drug resistance and improve treatment efficacy.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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