Topographical Quantification of Retinal Fluid in Type 3 MNV and Associations With Short-Term Visual Outcomes.

Autor: Berni A; The IRCCS San Raffaele Scientific Institute (A.B., C.B., U.I., F.B.), Milan, Italy; Vita-Salute San Raffaele University Milan (A.B., C.B., U.I., F.B.), Milan, Italy., Oakley JD; Voxeleron Inc. (J.D.O., D.B.R.), Austin, Texas, United States., Dolz-Marco R; Unit of Macula, Oftalvist Clinic (R.D.-M., R.G.-P.), Valencia, Spain., Gallego-Pinazo R; Unit of Macula, Oftalvist Clinic (R.D.-M., R.G.-P.), Valencia, Spain., Cimorosi F; Department of Surgical Sciences, University of Turin (F.C., A.G., M.R., E.B.), Turin, Italy; Department of Ophthalmology, City of Health and Science Hospital (F.C., A.G., M.R., E.B.), Turin, Italy., Ghilardi A; Department of Surgical Sciences, University of Turin (F.C., A.G., M.R., E.B.), Turin, Italy; Department of Ophthalmology, City of Health and Science Hospital (F.C., A.G., M.R., E.B.), Turin, Italy., Russakoff DB; Voxeleron Inc. (J.D.O., D.B.R.), Austin, Texas, United States., Barresi C; The IRCCS San Raffaele Scientific Institute (A.B., C.B., U.I., F.B.), Milan, Italy; Vita-Salute San Raffaele University Milan (A.B., C.B., U.I., F.B.), Milan, Italy., Introini U; The IRCCS San Raffaele Scientific Institute (A.B., C.B., U.I., F.B.), Milan, Italy; Vita-Salute San Raffaele University Milan (A.B., C.B., U.I., F.B.), Milan, Italy., Reibaldi M; Department of Surgical Sciences, University of Turin (F.C., A.G., M.R., E.B.), Turin, Italy; Department of Ophthalmology, City of Health and Science Hospital (F.C., A.G., M.R., E.B.), Turin, Italy., Bandello F; The IRCCS San Raffaele Scientific Institute (A.B., C.B., U.I., F.B.), Milan, Italy; Vita-Salute San Raffaele University Milan (A.B., C.B., U.I., F.B.), Milan, Italy., Borrelli E; Department of Surgical Sciences, University of Turin (F.C., A.G., M.R., E.B.), Turin, Italy; Department of Ophthalmology, City of Health and Science Hospital (F.C., A.G., M.R., E.B.), Turin, Italy. Electronic address: borrelli.enrico@yahoo.com.
Jazyk: angličtina
Zdroj: American journal of ophthalmology [Am J Ophthalmol] 2024 Aug 31; Vol. 269, pp. 181-188. Date of Electronic Publication: 2024 Aug 31.
DOI: 10.1016/j.ajo.2024.08.024
Abstrakt: Purpose: This study aims to quantify the volume of intraretinal fluid (IRF), subretinal fluid (SRF), and subretinal pigment epithelium (sub-RPE) fluid in treatment-naïve Type 3 macular neovascularization (MNV) eyes with age-related macular degeneration (AMD) and to investigate the correlation of these fluid volumes with visual acuity (VA) outcomes at baseline and following antivascular endothelial growth factor (VEGF) treatment.
Design: Retrospective, clinical cohort study.
Methods: In this study, we analyzed patients diagnosed with exudative AMD and treatment-naïve Type 3 MNV undergoing a loading dose of anti-VEGF therapy. Using a validated deep-learning segmentation strategy, we processed optical coherence tomography (OCT) B-scans to segment and quantify IRF (i.e., both in the inner and outer retina), SRF, and sub-RPE fluid volumes at baseline. The study correlated baseline fluid volumes with baseline and short-term VA outcomes postloading dose of anti-VEGF injections.
Results: Forty-six eyes from 46 patients were included in this study. Visual acuity was 0.51 ± 0.30 LogMAR at baseline and 0.33 ± 0.20 LogMAR after the loading dose of anti-VEGF (P = .001). Visual acuity at the follow-up visit was 0.40 ± 0.17 LogMAR in patients with no complete resolution of retinal fluid and 0.31 ± 0.20 LogMAR in eyes without retinal fluid after treatment (P = .225). In the multivariable analysis, the IRF volume in the inner retina (P = .032) and the distance of the MNV from the fovea (P = .037) were predictors of visual acuity at baseline. The baseline IRF volume in the inner retina also predicted the visual acuity at follow-up (P = .023).
Conclusion: The present study highlights the fluid volume in the inner retina as a crucial predictor of short-term visual outcomes in Type 3 MNV, underscoring the detrimental effect of IRF on neuroretinal structures.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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