Improvement of olfactory function in AD mice mediated by immune responses under 40 Hz light flickering.

Autor: Hu J; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China., Liu X; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China., Wang J; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China., Yang Q; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; School of Pharmacy, Zhejiang University, Hangzhou, Zhejiang 310058, China., Li W; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China., Yang J; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China., Zhang W; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China., Zeng L; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China. Electronic address: zenglh@hzcu.edu.cn., Li S; Department of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China. Electronic address: liss0220@hzcu.edu.cn.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2024 Nov 01; Vol. 842, pp. 137958. Date of Electronic Publication: 2024 Aug 30.
DOI: 10.1016/j.neulet.2024.137958
Abstrakt: Background: 40 Hz light flickering has shown promise as a non-invasive therapeutic approach for alleviating both pathological features and cognitive impairments in Alzheimer's disease (AD) model mice and AD patients. Additionally, vision may influence olfactory function through cross-modal sensory interactions.
Objective: To investigate the impact of 40 Hz light flickering on olfactory behavior in AD model mice and to explore the underlying mechanisms of this intervention.
Methods: We used immunofluorescence techniques to observe the activation of the olfactory bulb (OB) in C57BL/6J mice under 40 Hz light flickering. A buried food test was conducted to evaluate olfactory behavior in AD mice. Additionally, RNA sequencing technology was employed to detect transcriptional alterations in the OBs of AD mice following light stimulation.
Results: 40 Hz light flickering was found to effectively activate the OB. This stimulation led to enhanced olfactory behavior and did not alter P-tau protein mRNA levels within the OBs of AD mice. RNA sequencing revealed significant transcriptional changes in the OBs under flickering, particularly related to immune responses.
Conclusion: Vision can influence olfactory function through cross-modal sensory interactions in rodent models. 40 Hz light stimulation improved olfactory performance in AD mice. However, the improvement in olfaction in AD mice is not related to changes in P-tau mRNA levels. Instead, it may be associated with an altered immune response, providing a scientific basis for the clinical treatment of olfactory disorders in Alzheimer's disease.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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